Last reviewed · How we verify
NCT07375719
Nuclear Abnormalities in Gingival Epithelial Cells in Relation to Periodontal Disease
trial in Diabetes (DM) in 95 participants. Completed in 14 January 2026.
14 January 2026
Quick facts
| Lead sponsor | Çankırı Karatekin University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 95 |
| Start date | 1 March 2024 |
| Primary completion | 14 January 2026 |
| Estimated completion | 14 January 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Conditions studied
- Diabetes (DM) — all drugs for Diabetes (DM) →
- Periodontitis — all drugs for Periodontitis →
- Periodontitis (Stage 3) — all drugs for Periodontitis (Stage 3) →
- Micronuclei Count — all drugs for Micronuclei Count →
Sponsor
Çankırı Karatekin University
Who can join
40 and older, any sex, with Diabetes (DM) or Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Diabetes mellitus and periodontitis are two highly prevalent chronic diseases with a well-established bidirectional relationship. Poor glycemic control has been associated with increased periodontal inflammation and disease progression, while periodontal disease may adversely affect metabolic control in individuals with diabetes. Gingival epithelial cells, characterized by a high turnover rate, may reflect early nuclear and cellular alterations related to chronic inflammatory and metabolic conditions. The purpose of this cross-sectional observational study is to evaluate the association between glycemic control status, determined by hemoglobin A1c (HbA1c) levels, and nuclear morphological alterations in exfoliated gingival epithelial cells in patients with diabetes mellitus presenting with different severities of periodontal disease. Nuclear biomarkers, including micronuclei formation, binucleated cells, nuclear-to-cytoplasmic (N/C) ratio alterations, and perinuclear halo formation, are assessed using cytological analysis. Additionally, the study aims to investigate the combined and independent effects of periodontal disease severity and glycemic control on nuclear structural changes in gingival epithelial cells, comparing individuals with good (HbA1c \<7%) and poor (HbA1c ≥7%) glycemic control across different periodontal stages. This study seeks to contribute to the understanding of cellular-level alterations associated with chronic periodontal inflammation and metabolic dysregulation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07375719
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Diabetes (DM)
Currently open trials in the same condition.
- NCT07530575 — Limosilactobacillus Fermentum CRL 1446 - CONICET CASASCO · NA · active not recruiting
- NCT07167693 — Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes · Phase 1, PHASE2 · recruiting
- NCT07205978 — Nut Consumption and Prevention of Non-communicable Diseases: A Global Individual Participant Data Meta-analysis · active not recruiting
- NCT07252700 — Preventing Diabetes: Impact of an EMR-Based Intervention for Enhanced Pre-Diabetes Management in Primary Care · NA · recruiting
- NCT07285330 — Dietitian-Nutritionist vs. Day Hospital in the Metabolic Control of Patients With Type 2 Diabetes · recruiting
Other Çankırı Karatekin University trials
Trials by the same sponsor.
- NCT07326267 — School-Based Sensory Processing and Daily Living Skills-Focused Occupational Therapy Program · NA · not yet recruiting
- NCT07512544 — Building Sustainability Competencies in Future Nurses · NA · not yet recruiting
- NCT07266870 — Effect of CORE on Knowledge and Attitude Levels Regarding Pain Assessment · NA · completed
- NCT07306468 — Effects of Schizophrenia and Bipolar Disorder on Exercise Capacity, Pulmonary Function, and Quality of Life · recruiting
- NCT07207655 — Knowledge and Beliefs of Hearing Impaired Individuals Regarding Human Papillomavirus (HPV) · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07375719 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Çankırı Karatekin University
- Last refreshed: 29 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07375719.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing