Last reviewed · How we verify
NCT07374991: A Prospective
Clinical and Molecular Effects of N-Acetylcysteine Treatment in COVID-19-Related Acute Respiratory Distress Syndrome
NA trial testing N-Acetylcysteine (NAC) in COVID-19-Associated Acute Respiratory Distress Syndrome (ARDS) in 59 participants. Completed in 10 October 2022.
10 June 2022
Quick facts
| Lead sponsor | University of Gaziantep |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 59 |
| Start date | 1 November 2020 |
| Primary completion | 10 June 2022 |
| Estimated completion | 10 October 2022 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- N-Acetylcysteine (NAC)
Conditions studied
- COVID-19-Associated Acute Respiratory Distress Syndrome (ARDS) — all drugs for COVID-19-Associated Acute Respiratory Distress Syndrome (ARDS) →
Sponsor
University of Gaziantep
Who can join
18 and older, any sex, with COVID-19-Associated Acute Respiratory Distress Syndrome (ARDS). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Prospective, randomized, double-blind, placebo-controlled clinical trial evaluating the clinical and molecular effects of intravenous N-acetylcysteine (NAC) in patients with COVID-19-associated acute respiratory distress syndrome (ARDS) treated in the intensive care unit. The study assessed inflammatory and thromboinflammatory biomarkers, hypoxia-related gene expression (HIF-1α, ACE2, CD147), and clinical outcomes including mortality and length of ICU stay.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07374991
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of N-Acetylcysteine (NAC)
Trials testing the same drug.
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- NCT03197103 — The Impact of N-Acetylcysteine on Volumetric Retention of Autologous Fat Graft for Breast Asymmetry Correction · Phase 4 · unknown
- NCT02723162 — Translational Neuropsychopharmacology Research of Nicotine Addiction · Phase 2 · completed
- NCT00780962 — N-Acetylcysteine to Prevent Radiocontrast Nephropathy in Emergency Department Patients · Phase 2 · completed
Other University of Gaziantep trials
Trials by the same sponsor.
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- NCT07512297 — Pain Control During ESWL Using Non-Opioid Analgesics · Phase 4 · not yet recruiting
- NCT07484789 — Effect of Mindfulness-based Psychoeducation in Depression · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07374991 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Gaziantep
- Last refreshed: 29 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07374991.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing