Who is sponsoring NCT07368738?

NCT07368738 is sponsored by Horizon Health Network.

What drugs are being tested in NCT07368738?

Interventions in NCT07368738: IV midazolam, IV fentanyl, IV acetaminophen, IV ketorolac.

What condition does NCT07368738 study?

NCT07368738 studies Extracorporeal Shockwave Lithotripsy.

Is NCT07368738 still recruiting?

NCT07368738 is currently enrolling by invitation. Last updated 7 April 2026.

Last reviewed 2026-04-07 · How we verify

NCT07368738

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intravenous Acetaminophen and Ketorolac for Pain Management During Extracorporeal Shockwave Lithotripsy: A Quasi-Randomized Controlled Trial

ENROLLING BY INVITATION Phase 4 Last updated 7 April 2026

What this trial tests

Phase 4 trial testing IV midazolam in Extracorporeal Shockwave Lithotripsy in 266 participants. Enrolling by invitation.

Timeline

1 April 2026

Primary endpoint
1 April 2027

1 April 2027

Quick facts

Lead sponsor	Horizon Health Network
Phase	Phase 4
Status	ENROLLING BY INVITATION
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	supportive care
Enrollment	266
Start date	1 April 2026
Primary completion	1 April 2027
Estimated completion	1 April 2027
Sites	1 location across Canada

Drugs / interventions tested

IV midazolam — full drug profile →
IV fentanyl — full drug profile →
IV acetaminophen — full drug profile →
IV ketorolac — full drug profile →

Conditions studied

Extracorporeal Shockwave Lithotripsy — all drugs for Extracorporeal Shockwave Lithotripsy →

Sponsor

Horizon Health Network

Who can join

19 and older, any sex, with Extracorporeal Shockwave Lithotripsy. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Pain as Assessed by the NRS
Time frame: Before the procedure, and 30 minutes after the procedure
The numeric rating scale (NRS) will be used to quantify pain. Scores range from 0 (no pain) to 10 (worst pain).

Sponsor's own description

The goal of this clinical trial is to learn if a non-opioid pain medicine regimen works as well as or better than a standard opioid-based regimen to manage pain during extracorporeal shockwave lithotripsy (ESWL) in adults. The main questions it aims to answer are: Does the non-opioid regimen lead to similar or better pain control during the procedure? Does the non-opioid regimen lead to similar or better procedure tolerability and side effect profile? The non-opioid regimen will use intravenous (IV) midazolam plus IV acetaminophen and IV ketorolac, and the standard opioid-based regimen will use IV midazolam plus IV fentanyl. Participants will be randomly assigned to receive one of the two medication regimens during ESWL, and asked to rate their pain before the procedure and 30 minutes after the procedure.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other Horizon Health Network trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07368738 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Horizon Health Network
Last refreshed: 7 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07368738.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing