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NCT07335042
Prediction Model for MINS After Major Hepatobiliary Surgery
trial testing Major Hepatobiliary Surgery in Myocardial Injury After Noncardiac Surgery (MINS) in 1,800 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Beijing Tsinghua Chang Gung Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,800 |
| Start date | 11 June 2025 |
| Primary completion | 31 December 2026 |
| Estimated completion | 30 June 2027 |
| Sites | 6 locations across China |
Drugs / interventions tested
- Major Hepatobiliary Surgery
Conditions studied
- Myocardial Injury After Noncardiac Surgery (MINS) — all drugs for Myocardial Injury After Noncardiac Surgery (MINS) →
- Postoperative Complications — all drugs for Postoperative Complications →
- Liver Neoplasm — all drugs for Liver Neoplasm →
- Hepatobiliary Diseases — all drugs for Hepatobiliary Diseases →
Sponsor
Beijing Tsinghua Chang Gung Hospital
Who can join
Adults 18 to 85, any sex, with Myocardial Injury After Noncardiac Surgery (MINS) or Postoperative Complications. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery. The study adopts a nested modeling strategy, starting with baseline risk factors (e.g., RCRI) and stepwise incorporating hepatic inflow occlusion strategies (specifically comparing SPVO vs. Pringle maneuver) and routine intraoperative biomarkers. The model's performance will be evaluated using AUC, Net Reclassification Improvement (NRI), and Decision Curve Analysis (DCA), followed by interpretability analysis using SHAP values and external validation in an independent cohort.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07335042
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
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Related trials
Other recruiting trials for Myocardial Injury After Noncardiac Surgery (MINS)
Currently open trials in the same condition.
- NCT06279000 — Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery · Phase 3 · recruiting
- NCT07094321 — Study on the Correlation Between Intraoperative Hypotension and Postoperative Myocardial Injury · active not recruiting
- NCT05279651 — Ivabradine for Prevention of Myocardial Injury After Noncardiac Surgery Trial (PREVENT-MINS) · Phase 3 · active not recruiting
Other Beijing Tsinghua Chang Gung Hospital trials
Trials by the same sponsor.
- NCT07123675 — AI-Assisted Blood Pressure Control During Anesthesia · NA · not yet recruiting
- NCT07152496 — Host-Microbe Interactions in Biliary Dilatation · not yet recruiting
- NCT07330271 — PTC-Guided Therapy for Peritoneal Mesothelioma · NA · recruiting
- NCT07328737 — One vs Three HIPEC Cycles After CRS for Pseudomyxoma Peritonei · NA · recruiting
- NCT07044947 — Oteseconazole in the Treatment of Adults With Vulvovaginal Candidiasis（VVC） · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07335042 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Beijing Tsinghua Chang Gung Hospital
- Last refreshed: 12 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07335042.
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