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NCT06279000: COLCAT
Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery
Phase 3 trial testing Colchicine in Cardiovascular Diseases in 880 participants. Currently enrolling.
30 March 2028
Quick facts
| Lead sponsor | Cantonal Hospital of St. Gallen |
|---|---|
| Phase | Phase 3 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 880 |
| Start date | 20 April 2025 |
| Primary completion | 30 March 2028 |
| Estimated completion | 30 March 2029 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Colchicine (COLCHICINE) — full drug profile →
- Placebo
Conditions studied
- Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
- Cardiovascular Complication — all drugs for Cardiovascular Complication →
- Perioperative Complication — all drugs for Perioperative Complication →
- Myocardial Injury — all drugs for Myocardial Injury →
Sponsor
Cantonal Hospital of St. Gallen
Who can join
45 and older, any sex, with Cardiovascular Diseases or Cardiovascular Complication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery. However, research in recent years has yielded limited preventive and therapeutic measures for myocardial injury/MACE. Recent studies in patients with chronic and acute coronary artery disease have shown that colchicine administration can reduce the risk of cardiovascular events. These encouraging results in non-surgical patients ask for a similar investigation in patients undergoing major non-cardiac surgery. The aim of the proposed study is to investigate the effects of perioperative colchicine administration on the incidence of myocardial injury/MACE.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Clinical implications and feasibility of cerebral autoregulation-based precision blood pressure monitoring in major noncardiac surgery: A protocol for AUTOREGULATE-NONCARDIAC, a multicentre prospective cohort study and peri-operative precision medicine platform.
Wanner PM, Schindler C, Beqiri E, Smielewski P, et al · · 2026 · PMID 41684415 · DOI 10.1097/ea9.0000000000000093
Verify or expand the search:
- PubMed search for NCT06279000
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06279000 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cantonal Hospital of St. Gallen
- Last refreshed: 24 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06279000.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing