NCT06578182 (ECHO) is a Phase 3 clinical trial of Colchicine in Osteoarthritis, Knee, sponsored by Sint Maartenskliniek.

Who is sponsoring NCT06578182?

NCT06578182 is sponsored by Sint Maartenskliniek.

What drugs are being tested in NCT06578182?

Interventions in NCT06578182: Colchicine, Placebo.

What condition does NCT06578182 study?

NCT06578182 studies Osteoarthritis, Knee, Osteoarthritis, Hip.

Is NCT06578182 still recruiting?

NCT06578182 is currently recruiting now. Last updated 20 February 2025.

Last reviewed 2025-02-20 · How we verify

NCT06578182: ECHO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of ColcHicine on the Incidence of Knee or Hip Replacements

Recruiting now Phase 3 Last updated 20 February 2025

What this trial tests

Phase 3 trial testing Colchicine in Osteoarthritis, Knee in 1,410 participants. Currently enrolling.

Timeline

1 January 2025

Primary endpoint
31 March 2029

31 March 2029

Quick facts

Lead sponsor	Sint Maartenskliniek
Phase	Phase 3
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	1,410
Start date	1 January 2025
Primary completion	31 March 2029
Estimated completion	31 March 2029
Sites	1 location across Netherlands

Drugs / interventions tested

Colchicine (COLCHICINE) — full drug profile →
Placebo

Conditions studied

Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
Osteoarthritis, Hip — all drugs for Osteoarthritis, Hip →

Sponsor

Sint Maartenskliniek — full company profile →

Who can join

Adults 45 to 80, any sex, with Osteoarthritis, Knee or Osteoarthritis, Hip. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical trial is to evaluate the effect of treatment with colchicine 0.5mg once daily as compared to placebo in patients with knee or hip osteoarthritis on the incidence of first occurrence of knee or hip replacement. The main question it aims to answer is: Does colchicine lower the number of knee or hip replacements in participants with osteoarthritis? Researchers will compare colchicine to a placebo (a look-alike substance that contains no drug) to see if colchicine works to treat osteoarthritis. Participants will: * take colchicine every day for 3 tot 4.5 years * visit the clinic every year for check-up and tests such as blood samples and x-rays * fill in questionnaires every 3 months

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Design of a randomised, placebo-controlled, double-blind multicentre study assessing the effect of colchicine on the incidence of knee or hip replacements in symptomatic knee or hip osteoarthritis: the ECHO trial.
Heijman MWJ, van den Ende CHM, Cornel JH, Smolders JMH, et al · · 2025 · cited 1× · PMID 40228852 · DOI 10.1136/bmjopen-2024-098096

Verify or expand the search:

Other trials of Colchicine

Trials testing the same drug.

NCT07476625 — Efficacy and Safety of Thalidomide for Pediatric PFAPA Syndrome · NA · not yet recruiting
NCT06279000 — Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery · Phase 3 · recruiting
NCT06813079 — Using Tumor Models to Determine Treatments · Phase 2 · not yet recruiting
NCT06203977 — Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR) · Phase 1 · recruiting
NCT06212271 — Mechanistic Clinical Trial of Colchicine in Patients With Peripheral Artery Disease · EARLY_PHASE1 · completed

Other recruiting trials for Osteoarthritis, Knee

Currently open trials in the same condition.

NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting

Other Sint Maartenskliniek trials

Trials by the same sponsor.

NCT07160231 — REDO-JAK: Dose Reduction of Janus Kinase Inhibitors in Patients With Inflammatory Rheumatic Diseases · Phase 4 · recruiting
NCT06259227 — Cardiorespiratory Fitness Training in Patients With Incomplete Spinal Cord Injury · NA · terminated
NCT06214546 — Effect of Different Support Systems on Gait · NA · completed
NCT06516120 — Kinematics of Movements Provoked by an Augmented Reality App · recruiting
NCT06306352 — Vibrotactile Feedback in Exoskeletons · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06578182 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Sint Maartenskliniek
Last refreshed: 20 February 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06578182.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing