Last reviewed · How we verify
NCT07297901
App-based Breathing Program for Migraine Relief
NA trial testing Baseline Survey in Migraine in 30 participants. Enrolling by invitation.
30 May 2026
Quick facts
| Lead sponsor | Arizona State University |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | supportive care |
| Enrollment | 30 |
| Start date | 15 December 2025 |
| Primary completion | 30 May 2026 |
| Estimated completion | 30 May 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Baseline Survey
- Heart rate variability biofeedback — full drug profile →
- Sham Control Group
Conditions studied
- Migraine — all drugs for Migraine →
- Heart Rate Variability (HRV) — all drugs for Heart Rate Variability (HRV) →
- Autonomic Nervous System — all drugs for Autonomic Nervous System →
- Headache (Migraine) — all drugs for Headache (Migraine) →
Sponsor
Arizona State University
Who can join
18 and older, any sex, with Migraine or Heart Rate Variability (HRV). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Migraine is one of the most common neurological disorders, characterized by recurrent headaches, sensitivity to light and movement, nausea, and autonomic dysregulation. Although mind-body interventions like biofeedback have shown their efficacy, they remain underutilized due to barriers such as transportation, time constraints, lack of awareness, stigma, and cost. A targeted approach to enhancing HRV is HRV biofeedback (HRVB), a technique using visual or auditory feedback to help people regulate HRV through slow-paced breathing and positive emotional regulation to promote ANS balance and emotional resilience. Investigators will conduct a remotely delivered pilot RCT of an 8-week, 10 min/day, novel app-based HRVB intervention compared to a sham control intervention (matching intervention time and attention with no biofeedback component) in adult with chronic migraine. Investigators hypothesize data collected from the study will: a) support the feasibility and acceptability of the remotely delivered app-based HRVB intervention among adults with chronic migraine, and b) provide insights into refining the intervention by examining patterns of change in migraine and psychological outcomes from pre- to post-intervention.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07297901
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07297901 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Arizona State University
- Last refreshed: 22 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07297901.