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NCT07280975: PolySuture
Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure
NA trial testing Polyglactin 910 (Vicryl) Suture in Chronic Pain in 156 participants. Not yet recruiting.
30 June 2027
Quick facts
| Lead sponsor | Lady Reading Hospital, Pakistan |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 156 |
| Start date | 1 April 2026 |
| Primary completion | 30 June 2027 |
| Estimated completion | 30 July 2027 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Polyglactin 910 (Vicryl) Suture
- Polypropylene (Prolene) Suture
Conditions studied
- Chronic Pain — all drugs for Chronic Pain →
- Wound Dehiscence — all drugs for Wound Dehiscence →
- Surgical Site Infection (SSI) — all drugs for Surgical Site Infection (SSI) →
- Incisional Hernia — all drugs for Incisional Hernia →
Sponsor
Lady Reading Hospital, Pakistan
Who can join
Adults 18 to 70, any sex, with Chronic Pain or Wound Dehiscence. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy. The study will evaluate the rates of incisional hernia, surgical site infection (SSI), wound dehiscence, chronic pain, and suture sinus formation. Participants aged 18-70 years, undergoing either elective or emergency laparotomy, will be randomly assigned to receive either Polyglactin or Polypropylene sutures. The primary outcome measure is the incidence of incisional hernia at 6 months, with secondary outcomes including SSI, wound complications, and chronic pain. The study is particularly important in the context of Pakistan, where such comparative data is limited, and aims to provide evidence-based recommendations for optimal suture material selection in general surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07280975
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Other Lady Reading Hospital, Pakistan trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07280975 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lady Reading Hospital, Pakistan
- Last refreshed: 15 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07280975.
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