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NCT07279896
Determination of RNA/DNA Damage Associated With Oxidative Stress in Periodontitis Patients
trial in Periodontitis (Stage 3) in 88 participants. Completed in 15 August 2025.
4 August 2025
Quick facts
| Lead sponsor | Zehra Hasgül |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 88 |
| Start date | 5 May 2025 |
| Primary completion | 4 August 2025 |
| Estimated completion | 15 August 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Conditions studied
- Periodontitis (Stage 3) — all drugs for Periodontitis (Stage 3) →
- Smoking — all drugs for Smoking →
Sponsor
Zehra Hasgül
Who can join
Adults 18 to 65, any sex, with Periodontitis (Stage 3) or Smoking. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study looked at whether a type of gum disease called Stage III periodontitis and cigarette smoking are linked to higher levels of "oxidative stress." Oxidative stress can damage DNA and RNA, which are important parts of our cells. Two markers in saliva-8-OHdG (a sign of DNA damage) and 8-OHG (a sign of RNA damage)-were measured to understand this. Researchers included four groups of adults: smokers with periodontitis, non-smokers with periodontitis, healthy smokers, and healthy non-smokers. All participants had a dental exam, which checked things like gum inflammation, bleeding, and pocket depth. After the exam, an unstimulated saliva sample was collected from each person. The samples were tested in a laboratory using a sensitive method that measures oxidative damage. The study found that people with periodontitis had higher levels of DNA and RNA damage in their saliva than healthy people. The highest levels were seen in smokers with periodontitis. Even healthy smokers showed higher levels of oxidative stress than healthy non-smokers. In general, worse gum disease was linked to higher levels of oxidative damage. These results suggest that saliva tests for 8-OHdG and 8-OHG may help identify gum disease in a simple, non-invasive way. The findings also show that smoking adds to the body's oxidative stress, especially when gum disease is present. The study provides new information about how smoking and gum disease together may affect cell health.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07279896
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Related trials
Other recruiting trials for Periodontitis (Stage 3)
Currently open trials in the same condition.
- NCT06914596 — A Clinical Trial Comparing Overnight and 2x/Day for 30-minutes Use of the Emanate Perio PODS Post-SRP · NA · recruiting
- NCT06687005 — Comparative Analysis of Gremlin-1, Syndecan-4 and IL-1 Beta Levels in Gingival Crevicular Fluid Among İndividuals With P · active not recruiting
- NCT07523841 — Non-surgical Periodontitis Treatment With Aspirin and Omega-3 · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07279896 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zehra Hasgül
- Last refreshed: 12 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07279896.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing