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NCT06687005

Comparative Analysis of Gremlin-1, Syndecan-4 and IL-1 Beta Levels in Gingival Crevicular Fluid Among İndividuals With Periodontal Health and Stage III Periodontitis, Considering Both Smokers and Non-Smokers, Before and After Non-Surgical Periodontal Therapy

Active, enrolled Last updated 13 November 2024
What this trial tests

trial testing non-surgical periodontal therapy in Periodontitis (Stage 3) in 45 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline
1 April 2024
Primary endpoint
15 December 2024
15 December 2024

Quick facts

Lead sponsorTugba Aydin
StatusActive, enrolled
Study typeOBSERVATIONAL
Enrollment45
Start date1 April 2024
Primary completion15 December 2024
Estimated completion15 December 2024
Sites1 location across Turkey (Türkiye)

Drugs / interventions tested

Conditions studied

Sponsor

Tugba Aydin

Who can join

Adults 18 to 60, any sex, with Periodontitis (Stage 3) or Gremlin-1. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

eriodontitis is a complex disease characterized by the inflammation and destruction of the tissues supporting the teeth, and smoking can adversely affect the pathophysiological changes in this process. In an unhealthy periodontium, the host's inflammatory response products can be detected in the content of DOS, and the presence of these components is crucial in obtaining information about the pathogenesis of periodontal disease. Biochemical markers found in DOS are significantly helpful in determining the active stages and regions of the disease and in evaluating the host response to periodontal treatment. IL-1β has been determined to play a leading role in the pathogenic mechanism of periodontal tissue destruction, and the degree of inflammation in the tissues can be measured by IL-1β activity in DOS. Syndecan-4, a member of the transmembrane heparan sulfate proteoglycan family, regulates cellular activities such as tissue homeostasis, inflammation, fibrosis, and tumor metastasis. Gremlin-1 is a protein that inhibits BMP (Bone Morphogenetic Protein) signaling, influencing cell growth and tissue development. Gremlin-1 plays an important role in tissue repair and regeneration, modulating inflammatory processes and regulating cellular homeostasis. While recent studies have explained the role of Syndecan-4 and Gremlin-1 in inflammation, their effects on periodontal tissues are still quite limited in the literature. Our study aims to investigate the effects of smoking on these biomarkers by comparing the periodontal status before and after treatment of healthy, smoking, and non-smoking individuals with stage 3 periodontitis, with the goal of developing early diagnostic tools in the future.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Impact of smoking on gremlin-1, syndecan-4, and IL-1β responses to non-surgical periodontal therapy in stage 3 periodontitis: a comparative study with periodontally healthy controls.
    Bayrakdar YE, Aydın T, Laloğlu E. · · 2026 · PMID 41964715 · DOI 10.1007/s00784-026-06859-y

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Data sources for this page

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