NCT07237958 (DINOSE) is a NA clinical trial of Diesel Exhaust Particles in Alzheimer Disease (AD), sponsored by Umeå University.

Who is sponsoring NCT07237958?

NCT07237958 is sponsored by Umeå University.

What drugs are being tested in NCT07237958?

Interventions in NCT07237958: Diesel Exhaust Particles, Filtered air.

What condition does NCT07237958 study?

NCT07237958 studies Alzheimer Disease (AD), Dementia Alzheimer Type, Air Pollution Exposure.

Is NCT07237958 still recruiting?

NCT07237958 is currently completed. Last updated 20 November 2025.

Last reviewed 2025-11-20 · How we verify

NCT07237958: DINOSE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects on the Olfactory Epithelium and the Olfactory Nerve From Exposure to Diesel Exhaust

Completed NA Last updated 20 November 2025

What this trial tests

NA trial testing Diesel Exhaust Particles in Alzheimer Disease (AD) in 40 participants. Completed in 19 May 2023.

Timeline

1 February 2019

Primary endpoint
12 May 2023

19 May 2023

Quick facts

Lead sponsor	Umeå University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	diagnostic
Enrollment	40
Start date	1 February 2019
Primary completion	12 May 2023
Estimated completion	19 May 2023
Sites	1 location across Sweden

Drugs / interventions tested

Diesel Exhaust Particles — full drug profile →
Filtered air

Conditions studied

Alzheimer Disease (AD) — all drugs for Alzheimer Disease (AD) →
Dementia Alzheimer Type — all drugs for Dementia Alzheimer Type →
Air Pollution Exposure — all drugs for Air Pollution Exposure →

Sponsor

Umeå University

Who can join

Adults 20 to 70, any sex, with Alzheimer Disease (AD) or Dementia Alzheimer Type. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this study is to study the effect exposure to air pollution and its effect on development of dementia. Does the diesel exhaust change the function of the olfactory system? Have the exposures measurable effects on the sense of smell and cognitive ability? Forty people are exposed to diesel exhaust exhaust and filtered air. The exposures are blinded and in a randomized order. Both groups undergo biopsies of the olfactory epithelium in the nose under local anesthesia after the exposures and after performing cognitive test.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Endoscopy-guided bilateral olfactory mucosal biopsy: a safe and reproducible outpatient technique.
Muala A, Buckland R, Olofsson K, Penttilä E, et al · · 2026 · PMID 41914127 · DOI 10.1080/00016489.2026.2640210

Verify or expand the search:

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Other Umeå University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07237958 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Umeå University
Last refreshed: 20 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07237958.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing