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NCT07231614
Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry
Phase 4 trial testing lidocaine + epinephrine 1:100,000 in Dental Pain in 100 participants. Not yet recruiting.
25 December 2025
Quick facts
| Lead sponsor | Universidad Austral de Chile |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 20 December 2025 |
| Primary completion | 25 December 2025 |
| Estimated completion | 25 January 2026 |
| Sites | 1 location across Chile |
Drugs / interventions tested
- lidocaine + epinephrine 1:100,000 — full drug profile →
- Articaine 4% with epinephrine 1:100,000
Conditions studied
- Dental Pain — all drugs for Dental Pain →
Sponsor
Universidad Austral de Chile — full company profile →
Who can join
Adults 18 to 65, any sex, with Dental Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Context: Lidocaine and articaine are two of the most commonly used local anesthetics in dentistry. Lidocaine has often been the anesthetic of choice in clinical practice, but in clinical experience, articaine has proven to be more effective in controlling pain during dental procedures. (Camps-Font, O. et al. 2020). There are still unanswered questions, such as which of the two local anesthetics is more effective in reducing pain? This could lead us to discuss which one to choose to reduce costs in the dental office. Objective: The objective of this project is to determine and compare the effectiveness of lidocaine and articaine in clinical contexts such as tooth extraction with infiltrative techniques, seeking to provide answers that will optimize the choice of anesthetic based on the patient and the procedure, thus improving pain management and reducing costs in the dental office. Design: Randomized double-blind experimental study, parallel groups. The control group received 2% lidocaine, and the experimental group received 4% articaine. The study will be conducted in accordance with the guidelines of the Consolidated Standards of Reporting Trials (CONSORT 2010). The probabilistic sampling technique is through simple randomization. The 100 patients who meet the inclusion criteria will be randomly assigned to the control and experimental groups in a 1:1 ratio. Expected results: articaine shows a lower percentage of extractions with anesthetic reinforcement and, therefore, a lower average number of additional tubes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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- PubMed search for NCT07231614
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Related trials
Other trials of lidocaine + epinephrine 1:100,000
Trials testing the same drug.
- NCT05767749 — Split Face Study of the Duration of Local Anesthetics · Phase 4 · completed
Other recruiting trials for Dental Pain
Currently open trials in the same condition.
- NCT07239505 — A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symp · NA · recruiting
- NCT06948162 — Exploration of the Utility of Dental-dedicated MRI for Dentistry · recruiting
- NCT05351099 — Dental Block for Pain Relief in ED Dental Pain Patients · recruiting
Other Universidad Austral de Chile trials
Trials by the same sponsor.
- NCT06704113 — Meloxicam Versus Ibuprofen for Pain Control After Third Molar Exodontia in Adult Patients · Phase 4 · not yet recruiting
- NCT06792864 — Effectiveness of 3D Bone Matrix in Cranioplasty · Phase 3 · enrolling by invitation
- NCT06773923 — Effectiveness of 3D-printed Patient-specific Resorbable Scaffolds for Maxillary Bone Regeneration · Phase 3 · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07231614 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidad Austral de Chile
- Last refreshed: 17 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07231614.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing