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NCT07210606: CSA-HF
Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment
Phase 4 trial testing Trazodone + PAP therapy in Sleep Disordered Breathing in 200 participants. Not yet recruiting.
30 June 2030
Quick facts
| Lead sponsor | VA Office of Research and Development |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 200 |
| Start date | 1 October 2026 |
| Primary completion | 30 June 2030 |
| Estimated completion | 31 December 2030 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Trazodone + PAP therapy — full drug profile →
- Oxygen + PAP therapy — full drug profile →
Conditions studied
- Sleep Disordered Breathing — all drugs for Sleep Disordered Breathing →
- Able Bodied — all drugs for Able Bodied →
Sponsor
VA Office of Research and Development — full company profile →
Who can join
18 and older, any sex, with Sleep Disordered Breathing or Able Bodied. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07210606
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other recruiting trials for Sleep Disordered Breathing
Currently open trials in the same condition.
- NCT05656365 — Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA · recruiting
- NCT04118387 — Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment · Phase 4 · recruiting
- NCT05589753 — Sleep Disordered Breathing With Opioid Use · Phase 1, PHASE2 · recruiting
- NCT03858244 — Idiopathic Scoliosis Progression and Sleep-disordered Breathing in Children · active not recruiting
Other VA Office of Research and Development trials
Trials by the same sponsor.
- NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
- NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
- NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
- NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
- NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07210606 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
- Last refreshed: 7 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07210606.
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