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NCT07193368: HYDRO-KNEE
Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis
trial testing Polyacrylamide hydrogel 2.5% intra-articular injection in Knee Osteoarthritis in 387 participants. Completed in 24 June 2025.
24 June 2025
Quick facts
| Lead sponsor | Feza Korkusuz MD |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 387 |
| Start date | 11 February 2023 |
| Primary completion | 24 June 2025 |
| Estimated completion | 24 June 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Polyacrylamide hydrogel 2.5% intra-articular injection — full drug profile →
Conditions studied
- Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
- Osteoarthritis — all drugs for Osteoarthritis →
- Osteoarthritis of the Knee — all drugs for Osteoarthritis of the Knee →
- Degenerative Joint Disease of the Knee — all drugs for Degenerative Joint Disease of the Knee →
Sponsor
Feza Korkusuz MD — full company profile →
Who can join
40 and older, any sex, with Knee Osteoarthritis or Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is designed to evaluate the effects of intra-articular injections of polyacrylamide hydrogel (Arthrosamid®) in patients with knee osteoarthritis. A total of 387 patients (593 knees) were treated across three medical centers in Türkiye. The purpose of the study is to determine whether this injection can reduce knee pain and improve physical function in everyday life. Pain is being measured using a Visual Analogue Scale (VAS), and function is being assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07193368
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07193368 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Feza Korkusuz MD
- Last refreshed: 25 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07193368.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing