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NCT07157241: OSADMS

Effect of Omega-3 Supplements on Stress, Anxiety, Depression, Memory and Sleep Quality Among Saudis

Completed NA Last updated 5 September 2025
What this trial tests

NA trial testing Intervention in Healthy Adults in 64 participants. Completed in 16 August 2024.

Timeline
27 February 2022
Primary endpoint
12 February 2024
16 August 2024

Quick facts

Lead sponsorUmm Al-Qura University
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment64
Start date27 February 2022
Primary completion12 February 2024
Estimated completion16 August 2024
Sites1 location across Saudi Arabia

Drugs / interventions tested

Conditions studied

Sponsor

Umm Al-Qura University

Who can join

Adults 18 to 65, any sex, with Healthy Adults or Anxiety. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study looked at whether taking omega-3 supplements can help reduce stress, anxiety, depression, and improve memory and sleep quality in Saudi adults who feel highly stressed or anxious. Omega-3 is a healthy fat found in fish oil that may help the brain and mood. A total of 64 adults took part. They were randomly split into two groups. One group took omega-3 capsules (500 mg EPA + 250 mg DHA) every day for three months. The other group took a placebo (an inactive oil). Neither the participants nor the researchers knew who was taking which capsules to keep the study fair. Before and after the three months, all participants completed simple questionnaires about their stress, anxiety, depression, sleep, and everyday memory. The results showed that people who took omega-3 had lower stress, anxiety, and depression scores and reported better sleep quality and memory compared to those who took the placebo. This suggests that taking omega-3 supplements may help improve mental wellbeing and sleep in people with high stress and anxiety.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. The effects of Omega-3 supplementation on stress, anxiety, depression, sleep quality, and everyday memory in individuals with psychological distress: A randomized, double-blind, placebo-controlled trial.
    Azhar W, Qadhi A, Abusudah W, Ghabashi M, et al · · 2026 · PMID 41461240 · DOI 10.1016/j.jad.2025.121055

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