Adults 7 to 13, any sex, with Reversible Pulpitis or Ibuprofen. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change in Pain Intensity From Baseline (Pre-Operative) to Immediately During the Procedure (Day 0), Measured by the Visual Analogue Scale (VAS)Primary· Pre-Operative (Baseline) and Immediately During the Procedure (Day 0)
Pain intensity will be assessed using the Visual Analogue Scale (VAS), which ranges from 0 (no pain) to 10 (worst imaginable pain). The change will be calculated as the score immediately during the procedure (Day 0) minus the Baseline (Pre-Operative) score. Higher scores indicate worse pain.
Group
Value
95% CI
Control Group
5.05
± 3.51
Ibuprofen Group
0.64
± 1.14
Change in Postoperative Pain Intensity From Baseline (Pre-Operative) to Day 1, Measured by the Visual Analogue Scale (VAS)Secondary· Pre-Operative (Baseline) and 1 days post-treatment (Day 1)
Pain intensity will be assessed using the Visual Analogue Scale (VAS), which ranges from 0 (no pain) to 10 (worst imaginable pain). The Baseline (Pre-Operative) VAS score will be compared with the VAS score reported by the participant on Day 1. On Day 1, participants will be contacted by phone and asked to rate their pain using the same VAS tool.
Group
Value
95% CI
Control Group
0.59
± 1.37
Ibuprofen Group
0.68
± 1.39
Change in Postoperative Pain Intensity From Baseline (Pre-Operative) to Day 7, Measured by the Visual Analogue Scale (VAS)Secondary· Pre-Operative (Baseline) and 3 days post-treatment (Day 3)
Pain intensity will be assessed using the Visual Analogue Scale (VAS), which ranges from 0 (no pain) to 10 (worst imaginable pain). The Baseline (Pre-Operative) VAS score will be compared with the VAS score reported by the participant on Day 3. On Day 3, participants will be contacted by phone and asked to rate their pain using the same VAS tool.
Group
Value
95% CI
Control Group
0.14
± 0.47
Ibuprofen Group
0.23
± 0.75
Change in Postoperative Pain Intensity From Baseline (Pre-Operative) to Day 7, Measured by the Visual Analogue Scale (VAS)Analogue Scale (VAS)Secondary· Pre-Operative (Baseline) and 7 days post-treatment (Day 7)
Pain intensity will be assessed using the Visual Analogue Scale (VAS), which ranges from 0 (no pain) to 10 (worst imaginable pain). The Baseline (Pre-Operative) VAS score will be compared with the VAS score reported by the participant on Day 7. On Day 7, participants will be contacted by phone and asked to rate their pain using the same VAS tool.
Group
Value
95% CI
Control Group
0.05
± 0.21
Ibuprofen Group
0.09
± 0.29
Sponsor's own description
Effective intraoperative pain management is vital in paediatric dentistry, especially during vital pulp therapy (VPT) for reversible pulpitis. Although NSAIDs are widely used postoperatively, their role in controlling pain during treatment is less understood. To investigate the effect of preoperative ibuprofen on pain perception and physiological stress during VPT in children.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
NCT07073573 — Evaluation of Pulpal Biomarkers in Vital Pulp Therapy
· NA
· active not recruiting
NCT07391124 — In Vivo Pulp Thermal Changes During Different Slenderization Techniques
· NA
· active not recruiting
NCT06844448 — The Effect of Different Risk Factors on the Success Rate of VPT
· recruiting
NCT06433297 — Comparative Evaluation of Indirect vs. Direct Pulp Capping in Deep Carious Mandibular Molars
· NA
· recruiting
NCT07101068 — Assessment of Pain and Anxiety During Infiltration Anesthesia Using Dental Anesthesia Injector Versus Conventional Syrin
· NA
· recruiting
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Inonu University
Last refreshed: 24 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07114198.