NCT07106398

The Effectiveness of rTMS on Improving Food Craving and Weight Control in Adults Without Serious Mental Illness

Recruiting now NA Last updated 11 August 2025

What this trial tests

NA trial testing repetitive transcranial magnetic stimulation in Food Cravings in 30 participants. Currently enrolling.

Timeline

4 July 2025

Primary endpoint
27 June 2027

27 June 2028

Quick facts

Lead sponsor	The University of Hong Kong
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	4 July 2025
Primary completion	27 June 2027
Estimated completion	27 June 2028
Sites	1 location across Hong Kong

Drugs / interventions tested

• repetitive transcranial magnetic stimulation

Conditions studied

• Food Cravings — all drugs for Food Cravings →
• rTMS — all drugs for rTMS →

Sponsor

The University of Hong Kong

Who can join

Adults 18 to 65, any sex, with Food Cravings or rTMS. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Department of Psychiatry \| Li Ka Shing Faculty of Medicine

The University of Hong Kong

The Effectiveness of rTMS on Improving Food Cravings and Weight Control

in Adults without Serious Mental Illness

Introduction

The investigators would like to invite participants to participate in an observational study on the efficacy of using magnetic fields to improve food cravings and weight control in adults without serious mental illness.

The research leader is Dr. Cheng Pak Wing, Assistant Professor, Department of Psychiatry, Queen Mary Hospital/HKU Li Ka Shing Faculty of Medicine.

Please read the following information carefully. If necessary, participants can discuss it with relatives, friends or doctors. If anything is unclear, or if participants would like more information, please ask us. Please carefully consider whether participants are willing to participate in this research.

Research Purpose

Food cravings are a common experience that can significantly impact an individual's mental and physical health. These intense desires for specific foods often lead to overconsumption of unhealthy foods, contributing to obesity, poor nutritional intake, and associated health conditions. Understanding the neural mechanisms behind food cravings is crucial for developing effective interventions to manage them.

rTMS is a non-invasive brain stimulation technique that uses magnetic fields to modulate neural activity in targeted brain regions. Over the years, rTMS has shown promise in treating various mental health conditions, including depression, obsessive-compulsive disorder (OCD) and eating disorders.

Research Methods

Participants

Healthy adults aged 18-65 with self-reported food cravings or weight control issues.

Treatment protocol

Six sessions of rTMS using the EXOMIND™ device, administered once or twice a week.

Each session will deliver 6,300 pulses at alternating frequencies of 12, 15, and 18 Hz, with a total duration of 24 minutes and 30 seconds.

The target site would be left dorsolateral prefrontal cortex (DLPFC), determined by the most common used 5-cm rule. The procedure would be conducted in the research centre with medical staff supported.

A checklist of potential adverse effects from TMS administration will be referenced from existing literature to monitor tolerability and adverse events during each session. Blood pressure and heart rate will be recorded at the beginning and end of each session.

Assessment

Participants will be assessed at three time points: baseline (pre-intervention), post-intervention, and four weeks post-intervention.

Assessments: Food Cravings Questionnaire-Trait (FCQ-T), Perceived Stress Scale (PSS), Patient Health Questionnaire-9 (PHQ-9), and BMI.

Demographics: Age, gender, years of education, place of birth, marital status, number of children, financial condition, household income, family history of eating problems will be collected upon study entry. Medical history in relation to mental illnesses and medications will also be assessed.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.