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NCT07095816
Acetaminophen Before Surgery Lowers Postop Pain in Pediatric Solid Tumor Patients (ERAS)
Phase 1 trial testing Acetaminophen in Analgesic in 182 participants. Completed in 30 March 2025.
27 February 2025
Quick facts
| Lead sponsor | Nanjing Children's Hospital |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 182 |
| Start date | 15 May 2023 |
| Primary completion | 27 February 2025 |
| Estimated completion | 30 March 2025 |
| Sites | 1 location across China |
Drugs / interventions tested
- Acetaminophen (Paracetamol) — full drug profile →
- Sterilized water — full drug profile →
Conditions studied
- Analgesic — all drugs for Analgesic →
- Enhanced Recovery After Surgery — all drugs for Enhanced Recovery After Surgery →
- Postoperative Pain — all drugs for Postoperative Pain →
- Acetaminophen — all drugs for Acetaminophen →
Sponsor
Nanjing Children's Hospital
Who can join
Adults 1 Month to 15, any sex, with Analgesic or Enhanced Recovery After Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pain is the predominant subjective symptom experienced during the perioperative period in pediatric patients with solid tumors. Intense pain may impede early postoperative activities and delay the recovery process. Preemptive analgesia，as a component of multimodal analgesia strategies，aims to mitigate pain by administering analgesic interventions prior to the application of a noxious stimulus. This approach seeks to diminish both peripheral and central sensitization to pain，thereby alleviating postoperative pain. Currently，while preoperative acetaminophen is widely used in adult surgeries，research is limited for its use in pediatrics. This study aims to evaluate the impact of preemptive acetaminophen on reducing postoperative pain in children with solid tumors under the mode of ERAS.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07095816
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07095816 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nanjing Children's Hospital
- Last refreshed: 31 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07095816.
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