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NCT07081685: ENDIM
Efficacy of Non-Invasive Neuromodulation on Pain in Migraine
NA trial testing repetitive Transcranial Magnetic Stimulation (rTMS) in rTMS Stimulation in 120 participants. Not yet recruiting.
31 July 2028
Quick facts
| Lead sponsor | University Hospital, Clermont-Ferrand |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 31 July 2025 |
| Primary completion | 31 July 2028 |
| Estimated completion | 31 July 2028 |
| Sites | 1 location across France |
Drugs / interventions tested
- repetitive Transcranial Magnetic Stimulation (rTMS)
- sham repetitive Magnetic Transcranial Stimulation (rTMS)
Conditions studied
- rTMS Stimulation — all drugs for rTMS Stimulation →
- Migraine — all drugs for Migraine →
Sponsor
University Hospital, Clermont-Ferrand
Who can join
18 and older, any sex, with rTMS Stimulation or Migraine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a prospective clinical study evaluating the analgesic efficacy of a non-medicated treatment: repeated transcranial magnetic stimulation (rTMS) of the primary motor cortex in chronic migraine (\> 7 headache days per month and failure of at least 3 drug treatments). To this end, the study involves a double-blind, randomized, comparative experimental protocol against a sham control condition via 2 parallel groups comprising 60 patients each (N= 120 in total). Randomized block design with stratification by center and type of migraine (episodic or chronic). 5 rTMS sessions will be performed, with one stimulation session every 2 weeks. One group will receive active stimulation at each session (high-frequency stimulation of the left primary motor cortex, 2000 pulses per session, 80% of resting motor threshold) and the other group placebo stimulation (sham). Depending on the randomization group, rTMS sessions will be carried out by trained experimenters in the investigating center where the patient has been included. The study is multicentric, with five centers, four of which are in the Auvergne-Rhône-Alpes region. Data will be centralized at the Clermont-Ferrand University Hospital, and statistical analysis will be carried out by the Clermont-Ferrand University Hospital's Clinical Research and Innovation Department. Principal difference analysis (active vs sham) performed in ITT; missing data processed by multiple imputation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07081685
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for rTMS Stimulation
Currently open trials in the same condition.
- NCT07197346 — Repetitive Transcranial Magnetic Stimulation Primed Self-controlled Practice on Motor Learning · NA · recruiting
- NCT06796725 — Prospective Exploratory Study on rTMS for Migraine Under the Guidance of MEG · NA · recruiting
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07081685 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Clermont-Ferrand
- Last refreshed: 23 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07081685.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing