Last reviewed · How we verify
NCT07066267
Adipose Stem Cell Mitochondria Supplementation to Oocytes (ASCENT)
NA trial testing Experimental in Female Infertility in 20 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | Sunkaky Medical Cooperation |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 25 April 2025 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Sri Lanka |
Drugs / interventions tested
- Experimental — full drug profile →
Conditions studied
- Female Infertility — all drugs for Female Infertility →
- Oocyte Competence — all drugs for Oocyte Competence →
- Mitochondria — all drugs for Mitochondria →
- Recurent Implantation Failures — all drugs for Recurent Implantation Failures →
Sponsor
Sunkaky Medical Cooperation
Who can join
Adults 29 to 39, female only, with Female Infertility or Oocyte Competence. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to investigate the potential of autologous adipose stem cell (ASC) mitochondrial transfer (ASCENT) to oocytes along with intracytoplasmic sperm injection (ICSI)as a means of enhancing embryo development and improving the success rate of in patients with a history of multiple IVF failures. Embryo quality plays a crucial role in determining the success of assisted reproductive technologies and directly contributes to repeated pregnancy failures. Several factors, including age, physiological conditions, genetics, and environmental influences, can significantly impact embryo quality. Oocytes, the largest cells in the human body, are heavily reliant on mitochondria. Mitochondria's role in providing energy for oocytes is crucial, and insufficient energy production has been linked to poor oocyte and embryo quality. Some human studies have shown that increasing oocyte mitochondrial mass can improve embryo quality in patients who have experienced repeated IVF failures.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Mitochondrial DAMPs as a critical driver in the development of acute graft versus host disease and emerging mitochondria targeted therapeutic strategies.
Raguraman V, Prabhu YD, Velmurugan GV, Hildebrandt GC, et al · · 2025 · cited 1× · PMID 41607789 · DOI 10.3389/fimmu.2025.1740433
Verify or expand the search:
- PubMed search for NCT07066267
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Sunkaky Medical Cooperation trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07066267 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sunkaky Medical Cooperation
- Last refreshed: 17 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07066267.
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