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NCT07045350: DEXPRF-3M
Dexamethasone-PRF in Mandibular Third Molar Surgery: Effect on Pain, Edema, and Trismus (DEXPRF-3M)
NA trial testing Platelet-rich fibrin (PRF) in Impacted Mandibular Third Molar in 16 participants. Completed in 23 July 2024.
25 April 2024
Quick facts
| Lead sponsor | Cumhuriyet University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 16 |
| Start date | 20 July 2023 |
| Primary completion | 25 April 2024 |
| Estimated completion | 23 July 2024 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Platelet-rich fibrin (PRF)
Conditions studied
- Impacted Mandibular Third Molar — all drugs for Impacted Mandibular Third Molar →
Sponsor
Cumhuriyet University
Who can join
Adults 18 to 25, any sex, with Impacted Mandibular Third Molar. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Brief Summary This clinical trial investigates the effects of platelet-rich fibrin (PRF) derived from dexamethasone-enriched blood on postoperative recovery following the surgical extraction of impacted mandibular third molars (wisdom teeth). The study aims to determine whether the addition of dexamethasone, a potent anti-inflammatory medication, to the blood used for PRF preparation can reduce postoperative pain, swelling, and limited mouth opening (trismus) more effectively than standard PRF. The study is designed as a randomized, split-mouth, double-blind clinical trial involving 16 patients who require bilateral extraction of impacted lower third molars. Each patient receives both treatments: one extraction socket treated with standard PRF and the other with dexamethasone-enriched PRF. Postoperative outcomes including pain intensity, edema, trismus, and analgesic consumption are recorded and analyzed. The results of this study could offer a safer and more effective method for managing discomfort after wisdom tooth removal, potentially improving patient quality of life and reducing the need for additional medications.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07045350
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
Other trials of Platelet-rich fibrin (PRF)
Trials testing the same drug.
- NCT07508033 — Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing · Phase 1, PHASE2 · recruiting
- NCT06567548 — Clinical Comparison of Alb-PRF vs PRF on Postoperative Morbidity Following FGG Harvesting · NA · recruiting
- NCT06905860 — Intra-articular Infiltration of Platelet-Rich Fibrin vs Corticosteroid in Mild to Moderate Knee Osteoarthritis · Phase 4 · not yet recruiting
- NCT07530068 — Adjacent Molar Outcomes After Third Molar Surgery With PRF or Collagen Sponge · NA · completed
- NCT07022860 — Study on Platelet-Rich Fibrin for Preserving Jawbone After Tooth Extraction Using CBCT Imaging in Adults · NA · completed
Other recruiting trials for Impacted Mandibular Third Molar
Currently open trials in the same condition.
- NCT07198282 — The Effect of Different Flap Closure Techniques on Postoperative Morbidity in Impacted Third Molar Surgery · NA · recruiting
- NCT07450638 — Effect of Preoperative Long-Acting Corticosteroids on Pain, Swelling, and Trismus After Impacted Lower Third Molar Surge · NA · active not recruiting
Other Cumhuriyet University trials
Trials by the same sponsor.
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- NCT07446699 — The Effect of Pushing Techniques Used During Childbirth on Women's Labor Duration, Pain, and Fatigue Levels · NA · active not recruiting
- NCT07298681 — The Effect of Benner's Jigsaw Teaching Technique Based on the Novice to Expert Model and Scenario-Based Peripheral Intra · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07045350 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cumhuriyet University
- Last refreshed: 1 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07045350.
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