NCT07508033 (MSC-EXO vs PRF) is a Phase 1, PHASE2 clinical trial of MSC-Derived Exosomes in Alveolar Bone Loss, sponsored by Al Salam University.

Who is sponsoring NCT07508033?

NCT07508033 is sponsored by Al Salam University.

What drugs are being tested in NCT07508033?

Interventions in NCT07508033: MSC-Derived Exosomes, Platelet-rich fibrin (PRF).

What condition does NCT07508033 study?

NCT07508033 studies Alveolar Bone Loss, Tooth Extraction, Bone Regeneration.

Is NCT07508033 still recruiting?

NCT07508033 is currently recruiting now. Last updated 2 April 2026.

Last reviewed 2026-04-02 · How we verify

NCT07508033: MSC-EXO vs PRF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing

Recruiting now Phase 1, PHASE2 Last updated 2 April 2026

What this trial tests

Phase 1, PHASE2 trial testing MSC-Derived Exosomes in Alveolar Bone Loss in 40 participants. Currently enrolling.

Timeline

15 January 2026

Primary endpoint
15 July 2026

1 August 2026

Quick facts

Lead sponsor	Al Salam University
Phase	Phase 1, PHASE2
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	40
Start date	15 January 2026
Primary completion	15 July 2026
Estimated completion	1 August 2026
Sites	1 location across Egypt

Drugs / interventions tested

MSC-Derived Exosomes — full drug profile →
Platelet-rich fibrin (PRF)

Conditions studied

Alveolar Bone Loss — all drugs for Alveolar Bone Loss →
Tooth Extraction — all drugs for Tooth Extraction →
Bone Regeneration — all drugs for Bone Regeneration →

Sponsor

Al Salam University

Who can join

Adults 20 to 45, any sex, with Alveolar Bone Loss or Tooth Extraction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluates two different treatments used to help the jawbone heal after a tooth is removed. When a tooth is extracted, the surrounding bone often shrinks, which can make it difficult to place dental implants later. Currently, doctors often use Platelet-Rich Fibrin (PRF), which is made from the patient's own blood, to help the area heal. This research compares PRF to a newer treatment using "exosomes" derived from stem cells. Exosomes are tiny particles that carry signals to tell the body to repair tissue and grow new bone. The goal of this study is to see if these exosomes work better than PRF at keeping the bone strong and thick after an extraction. Researchers will use specialized X-rays (CBCT) to measure the bone three months after the procedure to see which treatment provided better results.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Cell derived nanovesicles for oral and craniofacial tissue regeneration.
Zhong L, Marschall JS, Shin K, Sun H. · · 2026 · PMID 42065569 · DOI 10.1039/d6nr00456c

Verify or expand the search:

Other trials of MSC-Derived Exosomes

Trials testing the same drug.

NCT07146087 — Allogeneic Mesenchymal Stem Cell-Derived Exosome Therapy for Progressive Multiple Sclerosis · EARLY_PHASE1 · suspended

Other recruiting trials for Alveolar Bone Loss

Currently open trials in the same condition.

NCT07375004 — Injectable PRF in Non-Surgical Periodontal Treatment · NA · active not recruiting
NCT07449806 — Assessment of Labial Plate Thickness After Immediate Implant Placement Using Two Different Xenografts in the Esthetic Zo · NA · recruiting
NCT07419269 — Comparison of Customized Allogenic Versus Autogenous Bone Block Graft for Alveolar Ridge Augmentation · NA · recruiting
NCT06887582 — Crestal Sinus Lifting in Periodontally-Compromised Patients Utilizing Autologous Dentin Graft · NA · active not recruiting
NCT06887595 — Linear Micro-Perforation Ridge Split Approach · NA · active not recruiting

Other Al Salam University trials

Trials by the same sponsor.

NCT07450638 — Effect of Preoperative Long-Acting Corticosteroids on Pain, Swelling, and Trismus After Impacted Lower Third Molar Surge · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07508033 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Al Salam University
Last refreshed: 2 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07508033.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing