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NCT07034326

Electroacupuncture Combined With Immune Checkpoint Inhibitors as Adjuvant Therapy After Surgery for Early-stage Non-small Cell Lung Cancer

Recruiting now Phase 2, PHASE3 Last updated 24 June 2025
What this trial tests

Phase 2, PHASE3 trial testing Electroacupuncture combined with immunotherapy in Non-Small Cell Lung Cancer in 405 participants. Currently enrolling.

Timeline
1 January 2025
Primary endpoint
31 December 2028
31 December 2028

Quick facts

Lead sponsorKong Fanming
PhasePhase 2, PHASE3
StatusRecruiting now
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment405
Start date1 January 2025
Primary completion31 December 2028
Estimated completion31 December 2028
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

Kong Fanming — full company profile →

Who can join

Adults 18 to 80, any sex, with Non-Small Cell Lung Cancer or Electroacupuncture. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Postoperative immunoadjuvant therapy has been proven to significantly reduce the risk of recurrence after resectable NSCLC, and has become a new standard of postoperative adjuvant therapy for stage II-III NSCLC. Immunotherapy faces challenges such as immune resistance, heterogeneity of biomarker expression, and limitation of immune-suitable population. How to reduce the rate of recurrence and metastasis after surgery, enhance the therapeutic effect of immunotherapy, and then prolong the survival period and improve the quality of life, has become an urgent problem facing the current clinical. Based on the standards of evidence-based medicine, this study for the first time carried out a large sample, multi-center, randomized parallel controlled clinical study to obtain high-quality clinical evidence of the effectiveness and safety of electro-acupuncture and Zilongjin tablet synergic treatment, and formed a standard treatment plan of traditional Chinese medicine.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Harmonizing yin and yang, remodeling the microenvironment: the adjuvant potential of Chinese herbal medicine in tumor immunotherapy.
    Gao X, Han Y, Yang L, Fang H, et al · · 2026 · PMID 41959898 · DOI 10.3389/fonc.2026.1806602
  2. Research progress on traditional Chinese medicine-assisted immune checkpoint inhibitors therapy for solid tumors.
    Liu Z, Xie Y, He Y, Chen K, et al · · 2026 · PMID 41694353 · DOI 10.3389/fimmu.2026.1723860

Verify or expand the search:

Other recruiting trials for Non-Small Cell Lung Cancer

Currently open trials in the same condition.

Other Kong Fanming trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

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