Last reviewed · How we verify
NCT07019636: T-REX
Direct Extubation Versus Extubation After a Spontaneous Breathing Trial in Patients at Low Risk of Extubation Failure
NA trial testing Weaning strategy with direct extubation (no spontaneous breathing trial) in Weaning From Mechanical Ventilation, Extubation in 314 participants. Not yet recruiting.
18 September 2027
Quick facts
| Lead sponsor | Assistance Publique - Hôpitaux de Paris |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 314 |
| Start date | 15 September 2025 |
| Primary completion | 18 September 2027 |
| Estimated completion | 15 October 2027 |
| Sites | 1 location across France |
Drugs / interventions tested
- Weaning strategy with direct extubation (no spontaneous breathing trial)
- Weaning strategy with extubation only after a successful spontaneous breathing
Conditions studied
- Weaning From Mechanical Ventilation, Extubation — all drugs for Weaning From Mechanical Ventilation, Extubation →
Sponsor
Assistance Publique - Hôpitaux de Paris — full company profile →
Who can join
Adults 18 to 65, any sex, with Weaning From Mechanical Ventilation, Extubation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized controlled open label trial aims at comparing a weaning strategy including a spontaneous breathing trial as a prerequisite for extubation to a weaning strategy without a spontaneous breathing trial (direct extubation) in patients with readiness to be weaned criteria and considered at low risk of extubation failure. The main endpoint will be the proportion of patients successfully extubated within the 24 hours after randomization as compared to extubation after a successful spontaneous breathing trial (SBT).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07019636
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07019636 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Assistance Publique - Hôpitaux de Paris
- Last refreshed: 19 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07019636.
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