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NCT06982209
ANI-Guided Anesthetic Desflurane Consumption
NA trial testing Analgesia/Nociception Index (ANI) in Postoperative Pain in 125 participants. Completed in 30 April 2025.
30 April 2024
Quick facts
| Lead sponsor | Wonkwang University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 125 |
| Start date | 5 February 2024 |
| Primary completion | 30 April 2024 |
| Estimated completion | 30 April 2025 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- Analgesia/Nociception Index (ANI)
Conditions studied
- Postoperative Pain — all drugs for Postoperative Pain →
- General Anesthesia — all drugs for General Anesthesia →
- Laparoscopic Cholecystectomy — all drugs for Laparoscopic Cholecystectomy →
Sponsor
Wonkwang University Hospital
Who can join
Adults 19 to 65, any sex, with Postoperative Pain or General Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
General anesthesia requires precise titration of inhaled anesthetics like desflurane and opioids like remifentanil to balance sedation, analgesia, and hemodynamic stability. The Analgesia/Nociception Index (ANI), derived from heart rate variability (HRV), quantifies parasympathetic tone to assess nociception-antinociception balance on a 0-100 scale, with lower values indicating nociceptive stress. ANI analyzes high-frequency HRV components, reflecting parasympathetic inhibition during painful stimuli, making it a reliable indicator of intraoperative nociception. Studies validate the utility of ANI in detecting nociceptive events during laparoscopic surgery. ANI-guided opioid titration reduces opioid consumption and stabilizes hemodynamics, enhancing perioperative outcomes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06982209
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Analgesia/Nociception Index (ANI)
Trials testing the same drug.
- NCT05049577 — Preanesthetic Analgesia/Nociception Index (ANI) and Propofol Injection Pain · NA · completed
Other recruiting trials for Postoperative Pain
Currently open trials in the same condition.
- NCT07452120 — DIPB vs. SIFIB for Postoperative Analgesia After Hip Surgery · NA · recruiting
- NCT07396688 — Comparative Evaluation of the Effects of Calcium Hydroxide and BIO-C Temp Medicaments on Postoperative Pain in Patients · NA · recruiting
- NCT07413055 — Comparative Efficacy Of 4 mg VS. 8 mg Submucosal Dexamethasone In Postoperative Pain Management After Dental Implant Sur · Phase 3 · recruiting
- NCT07496086 — External Oblique Intercostal Block Versus Transversus Abdominis Plane Combined With Rectus Sheath Block on Postoperative · NA · recruiting
- NCT07396545 — External Oblique Intercostal Block Versus Erector Spinae Plane Block on Postoperative Pain in Laparoscopic Radical Gastr · NA · recruiting
Other Wonkwang University Hospital trials
Trials by the same sponsor.
- NCT07389954 — Personalized Music and Dreaming During Propofol Sedation · NA · completed
- NCT07360262 — Gastric Emptying Recovery After GLP-1 RA Cessation · completed
- NCT07260890 — Paired Comparison of SVV and PVI Accuracy · recruiting
- NCT06970249 — Music Timing for Emergence Delirium in Elderly · NA · completed
- NCT07097454 — Effectiveness of Hypotension Prediction Index (HPI) in Preventing Hypotension in the Post-Anesthesia Care Unit (PACU) · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06982209 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Wonkwang University Hospital
- Last refreshed: 21 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06982209.
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