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NCT06950944
Efficacy and Safety of Repeated-use Middle Cut Off Membrane Dialyzers in Hemodialysis Patients
NA trial testing Theranova 500 in Hemodialysis in 48 participants. Completed in 30 April 2024.
31 March 2024
Quick facts
| Lead sponsor | Khon Kaen University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 48 |
| Start date | 1 January 2024 |
| Primary completion | 31 March 2024 |
| Estimated completion | 30 April 2024 |
| Sites | 1 location across Thailand |
Drugs / interventions tested
- Theranova 500
Conditions studied
- Hemodialysis — all drugs for Hemodialysis →
- Hemodialysis Treatment — all drugs for Hemodialysis Treatment →
- Dialysis Adequacy — all drugs for Dialysis Adequacy →
Sponsor
Khon Kaen University
Who can join
Adults 18 to 80, any sex, with Hemodialysis or Hemodialysis Treatment. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to compare the efficacy of uremic toxin and inflammatory cytokine clearance by using reprocessing middle cutoff membrane (MCO) dialyzer in chronic hemodialysis patients. The main questions it aims to answer are: * To evaluate efficacy of uremic toxin and inflammatory cytokine clearance and safty of hemodialysis with reprocessing MCO dialyzer compared with new MCO dialyzer * To compare efficacy of uremic toxin and inflammatory cytokine clearance between 2 types of MCO dialyzer which availble in Thailand (Theranova 500 and Elisio 21Hx). Participants will randomized to 2 types of MCO groups after that they will receive hemodialysis by using study dialyzer with similar hemodialysis prescription. The dialyzer in this study were reprocessing by standard hospital protocol. Researchers will compare 2 types of dialyzer groups to see efficacy of uremic toxin and inflammatory cytokine clearance and safety of use reprocessing dialyzer.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Comparative Efficacy of Reused Medium Cut-Off Dialyzers on Uremic Toxin and Cytokine Clearance: A Randomized Controlled Trial.
Lukkanalikitkul E, Jirayuphat N, Anutrakulchai S. · · 2025 · PMID 41010409 · DOI 10.3390/life15091468
Verify or expand the search:
- PubMed search for NCT06950944
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Khon Kaen University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06950944 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Khon Kaen University
- Last refreshed: 4 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06950944.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing