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NCT07278973: HD-OLDER
Hemodiafiltration Versus Hemodialysis in Older People
NA trial testing High-flux hemodialysis in Hemodialysis in 62 participants. Currently enrolling.
19 December 2026
Quick facts
| Lead sponsor | AUB Santé |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | other |
| Enrollment | 62 |
| Start date | 19 February 2026 |
| Primary completion | 19 December 2026 |
| Estimated completion | 19 December 2026 |
| Sites | 4 locations across France |
Drugs / interventions tested
- High-flux hemodialysis
- Hemodiafiltration
Conditions studied
- Hemodialysis — all drugs for Hemodialysis →
- Hemodiafiltration — all drugs for Hemodiafiltration →
- Fatigue Symptom — all drugs for Fatigue Symptom →
- Quality of Life of Patients — all drugs for Quality of Life of Patients →
Sponsor
AUB Santé
Who can join
85 and older, any sex, with Hemodialysis or Hemodiafiltration. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will compare the impact of two hemodialysis techniques on fatigue and post-dialysis recovery time in patients aged 85 years and older. These two techniques are high-flux hemodialysis (HD) and hemodiafiltration (HDF). Patients will receive the treatment over two periods: if period 1 is HD then period 2 will be HDF. Every patient will be his/her own control, this is why it is called cross-over. Each period will last three months. Between the two periods, patients will receive a traditional low-flux hemodialysis. These two techniques are widely used worldwide and their side-effects are well-known and do not put the patients at risk. HDF has been shown to improve survival in patients with a mean age of 58 years. But a previous study from the investigators' group showed that HDF causes a prolonged recovery time in older patients. This randomized trial aims to elucidate this question.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07278973
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of High-flux hemodialysis
Trials testing the same drug.
- NCT06526702 — Intradialytic Kinetics of Cardiac Biomarkers During Hemodialysis and Hemodiafiltration · NA · completed
- NCT03456232 — High-flux Hemodialysis Versus Hemodiafiltration for End-Stage Renal Disease · NA · unknown
- NCT03190629 — The Effect of On-line Hemodiafiltratrion on Nutritional Status and Body Composition · NA · completed
Other recruiting trials for Hemodialysis
Currently open trials in the same condition.
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- NCT07234890 — Study to Evaluate the Effects of AV-001 on HD-induced Brain Injury. · Phase 2 · recruiting
- NCT07512895 — The Effect of Progressive Muscle Relaxation Exercises on Depression and Fatigue in Patients Receiving Hemodialysis Treat · NA · recruiting
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- NCT07144332 — This Study is to Estimate the Efficacy of Hemodialysis Alone for Uric Acid Clearance in Patients on Hemodialysis. In Ord · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07278973 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by AUB Santé
- Last refreshed: 23 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07278973.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing