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NCT06940466
A Cognitive Intervention to Manage 'Brain Fog' in Menopause Transition: Feasibility Study
NA trial testing Online cognitive intervention in Menopause in 33 participants. Completed in 1 December 2025.
1 October 2025
Quick facts
| Lead sponsor | University College, London |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 33 |
| Start date | 27 June 2025 |
| Primary completion | 1 October 2025 |
| Estimated completion | 1 December 2025 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Online cognitive intervention
Conditions studied
- Menopause — all drugs for Menopause →
Sponsor
University College, London
Who can join
Adults 40 to 60, female only, with Menopause. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cognitive complaints at menopause transition (MT), often described as 'brain fog'; can include difficulty recalling words and numbers, misplacing items, trouble concentrating and forgetfulness. Whilst these difficulties resolve for most people, several years of reduced cognitive functioning can be highly damaging and result in problems including leaving work, depression and relationship breakdown. Study Aims: This project aims 1) to develop and finalise a cognitive intervention for the menopause, 2) To evaluate the feasibility, acceptability and preliminary effects of the intervention. 3) To evaluate the interventions preliminary effects on subjective and objective cognition Relevance: Traditionally Menopause Hormone Therapy (MHT) is offered to women with cognitive complaints due to its beneficial effect. However, many women are unable to take it due to medical reasons or choose not to. If this intervention is concluded as feasible and acceptable it may then be appropriate to conduct a full RCT of this intervention. It could reduce excess disability, potentially enabling people to remain at work and function better in daily life. Costs to the NHS might be reduced through decreased service and medication use.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Cognitive Stimulation Therapy in Menopause: Feasibility randomised controlled trial.
Aimee S, Faulkner A, Gilchrist H, Sethi S, et al · · 2026 · PMID 42148722 · DOI 10.1530/raf-26-0027
Verify or expand the search:
- PubMed search for NCT06940466
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University College, London trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06940466 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University College, London
- Last refreshed: 6 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06940466.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing