Last reviewed · How we verify
NCT06929416
Estrogen and Propofol Injection Pain
trial in Pain in 90 participants. Completed in 10 September 2025.
10 September 2025
Quick facts
| Lead sponsor | Konya City Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 90 |
| Start date | 2 May 2025 |
| Primary completion | 10 September 2025 |
| Estimated completion | 10 September 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Conditions studied
- Pain — all drugs for Pain →
- Estradiol — all drugs for Estradiol →
- Assisted Reproductive Techniques — all drugs for Assisted Reproductive Techniques →
Sponsor
Konya City Hospital
Who can join
Adults 18 to 45, female only, with Pain or Estradiol. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This prospective observational study investigates the relationship between serum estrogen concentration and the incidence and severity of propofol injection pain (PIP) in female patients undergoing general anesthesia. The study will include 90 ASA I-II female patients aged 18-45. One group will consist of IVF patients with elevated estrogen levels, while the control group will include patients with normal estrogen levels undergoing other elective procedures. Pain will be assessed using a standardized four-point behavioral pain scale. The findings may enhance understanding of hormonal influences on pain and contribute to improving patient comfort during anesthesia induction.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Association between supraphysiological estradiol levels and propofol injection pain: a prospective observational study.
Tutar MS, Erarkadas A, Yildirim SN, Korucu DG, et al · · 2026 · PMID 41965507 · DOI 10.1186/s12871-026-03823-x
Verify or expand the search:
- PubMed search for NCT06929416
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Konya City Hospital trials
Trials by the same sponsor.
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- NCT07295158 — Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06929416 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Konya City Hospital
- Last refreshed: 16 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06929416.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing