Last reviewed · How we verify
NCT06910241
Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs
Phase 3 trial testing Lidocaine in Laceration of Skin in 100 participants. Currently enrolling.
30 June 2027
Quick facts
| Lead sponsor | Florida Atlantic University |
|---|---|
| Phase | Phase 3 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 3 September 2025 |
| Primary completion | 30 June 2027 |
| Estimated completion | 30 June 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Lidocaine — full drug profile →
- Diphenhydramine (diphenhydramine) — full drug profile →
Conditions studied
- Laceration of Skin — all drugs for Laceration of Skin →
Sponsor
Florida Atlantic University
Who can join
18 and older, any sex, with Laceration of Skin. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06910241
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Lidocaine
Trials testing the same drug.
- NCT07488832 — Intravenous Lidocaine Infusion in Lumbar Fusion Surgery · NA · recruiting
- NCT07445191 — Efficacy of Triamcinolone-Lidocaine Mix in Trigger Points Injection of Masseter Muscle: Double-blinded, Randomized Contr · Phase 2, PHASE3 · not yet recruiting
- NCT07422558 — Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain · NA · not yet recruiting
- NCT06923787 — Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patient · Phase 2 · recruiting
- NCT07355049 — The Effect of Dexmedetomidine Versus Lidocaine on Emergence Agitation. · NA · not yet recruiting
Other recruiting trials for Laceration of Skin
Currently open trials in the same condition.
- NCT05383495 — Anxiolysis for Laceration Repair in Children · Phase 3 · recruiting
Other Florida Atlantic University trials
Trials by the same sponsor.
- NCT06645548 — Machine Learning and 3D Image-Based Modeling for Real-Time Body Weight and Body Composition Estimation During Emergency · NA · withdrawn
- NCT06646133 — Machine Learning and 3D Image-Based Modeling for Real-Time Body Weight and Body Composition Estimation During Emergency · withdrawn
- NCT07127510 — Brain NAD in Alzheimer's Disease · recruiting
- NCT07587957 — Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors · NA · recruiting
- NCT07216846 — The Geriatric Emergency Department Pharmacologic Harm Prevention Project · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06910241 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Florida Atlantic University
- Last refreshed: 7 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06910241.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing