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NCT06904716

The Study of Transcranial Magnetic Stimulation in the Regulation of Spinocerebellar Ataxia

Active, enrolled NA Last updated 1 April 2025
What this trial tests

NA trial testing Transcranial magnetic stimulation in Spinocerebellar Ataxia in 60 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline
1 May 2023
Primary endpoint
1 May 2025
1 May 2025

Quick facts

Lead sponsorFirst Affiliated Hospital of Chongqing Medical University
PhaseNA
StatusActive, enrolled
Study typeINTERVENTIONAL
Allocationnon randomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment60
Start date1 May 2023
Primary completion1 May 2025
Estimated completion1 May 2025
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

First Affiliated Hospital of Chongqing Medical University

Who can join

Adults 18 to 75, any sex, with Spinocerebellar Ataxia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Spinocerebellar ataxia (SCA) is a group of hereditary neurological diseases caused by gene mutations leading to degenerative changes in the cerebellum, brainstem, and spinal cord. A key pathogenic mechanism of SCA is the repeated expansion of cytosine - adenine - guanine (CAG) trinucleotides in the coding region of specific genes. These repeated expansions are translated into abnormally large polyglutamine (PolyQ) tracts in proteins. These polyglutamine (PolyQ) tracts can cause changes in the excitability of the cerebral cortex in SCA patients. Quantitative electroencephalogram analysis (qEEG) is a modern type of electroencephalogram analysis that uses complex mathematical algorithms to process, transform, and analyze EEG signals, bringing new technologies for EEG signal feature extraction: specific frequency band and signal complexity analysis, connectivity analysis, and network analysis. It is sensitive to early neurodegenerative lesions. Using spectral analysis, nonlinear dynamics analysis, and functional connectivity analysis, we can explore the changes in cortical excitability and abnormal brain networks in SCA patients. Currently, the exploration of the quantitative electroencephalogram characteristics of SCA patients is still insufficient.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

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Other trials of Transcranial magnetic stimulation

Trials testing the same drug.

Other recruiting trials for Spinocerebellar Ataxia

Currently open trials in the same condition.

Other First Affiliated Hospital of Chongqing Medical University trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

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