NCT06867224 is a NA clinical trial of Shame TUS-vmPFC in Alcohol Use Disorder (AUD), sponsored by Shanghai Mental Health Center.

Who is sponsoring NCT06867224?

NCT06867224 is sponsored by Shanghai Mental Health Center.

What drugs are being tested in NCT06867224?

Interventions in NCT06867224: Shame TUS-vmPFC, Active TUS-vmPFC.

What condition does NCT06867224 study?

NCT06867224 studies Alcohol Use Disorder (AUD), Transcranial Ultrasound Stimulation.

Is NCT06867224 still recruiting?

NCT06867224 is currently active, enrolled. Last updated 13 January 2026.

Last reviewed 2026-01-13 · How we verify

NCT06867224

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Transcranial Ultrasound Stimulation as a Neuromodulation Therapy for Craving and Relapse Behaviors in Alcohol Use Disorder.

Active, enrolled NA Last updated 13 January 2026

What this trial tests

NA trial testing Shame TUS-vmPFC in Alcohol Use Disorder (AUD) in 40 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

20 March 2025

Primary endpoint
20 September 2026

1 January 2027

Quick facts

Lead sponsor	Shanghai Mental Health Center
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	40
Start date	20 March 2025
Primary completion	20 September 2026
Estimated completion	1 January 2027
Sites	1 location across China

Drugs / interventions tested

Shame TUS-vmPFC
Active TUS-vmPFC

Conditions studied

Alcohol Use Disorder (AUD) — all drugs for Alcohol Use Disorder (AUD) →
Transcranial Ultrasound Stimulation — all drugs for Transcranial Ultrasound Stimulation →

Sponsor

Shanghai Mental Health Center — full company profile →

Who can join

Adults 18 to 60, any sex, with Alcohol Use Disorder (AUD) or Transcranial Ultrasound Stimulation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to evaluate the efficacy of transcranial ultrasound stimulation in reducing cravings and preventing relapse in individuals with alcohol use disorders. Utilizing a double-blind design, participants will be randomly assigned to receive either active accelerated transcranial ultrasound stimulation or a sham treatment.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Transcranial Ultrasound Stimulation as an Emerging Treatment for Substance use Disorder: Promise and Precaution.
Komarnyckyj M, Sherpa NN, Lawn W, Fouragnan E. · · 2026 · PMID 42079841 · DOI 10.1007/s40429-026-00734-2

Verify or expand the search:

Other recruiting trials for Alcohol Use Disorder (AUD)

Currently open trials in the same condition.

NCT07118618 — Probenecid Administration for Alcohol Craving and Consumption · Phase 2 · recruiting
NCT07040592 — Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide · Phase 2 · recruiting
NCT06949423 — Assessing the Impact of dTMS on Neural Targets Associated With Alcohol Use Disorder · NA · recruiting
NCT06070649 — The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD) · Phase 1 · recruiting
NCT06335407 — Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study · Phase 1 · recruiting

Other Shanghai Mental Health Center trials

Trials by the same sponsor.

NCT07480408 — Neural Mechanisms of the Sensorymotor Circuit in Sensory Phenomena in OCD · NA · not yet recruiting
NCT07479771 — tTIS Targeted of the Striatum as an Intervention for MUD Patients · NA · not yet recruiting
NCT07472673 — Transcranial Temporal Interference Stimulation Targeted of the Amygdala as an Intervention for Alcohol Use Disorder Pati · NA · not yet recruiting
NCT07484750 — Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD · NA · recruiting
NCT07311655 — Validation of the Accuracy of an AI-Based System for Diagnosing Anxiety Disorders · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06867224 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shanghai Mental Health Center
Last refreshed: 13 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06867224.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing