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NCT06861725
CARIES ARREST USING SILVER DIAMINE FLUORIDE VERSUS FISSURE SEALANT in OCCLUSAL DENTAL CARIOUS LESIONS: RANDOMIZED CONTROLLED TRIAL
NA trial testing Silver Diamine Fluoride (SDF) in Dental Caries in 76 participants. Not yet recruiting.
1 April 2026
Quick facts
| Lead sponsor | Cairo University |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 76 |
| Start date | 1 April 2025 |
| Primary completion | 1 April 2026 |
| Estimated completion | 1 May 2026 |
Drugs / interventions tested
- Silver Diamine Fluoride (SDF) — full drug profile →
- VOCO Fissurit
Conditions studied
- Dental Caries — all drugs for Dental Caries →
- Caries Arrested — all drugs for Caries Arrested →
- Silver Diamine Fluoride — all drugs for Silver Diamine Fluoride →
- Fissure Sealant — all drugs for Fissure Sealant →
Sponsor
Cairo University
Who can join
Adults 20 to 45, any sex, with Dental Caries or Caries Arrested. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this randomized clinical trial is to evaluate if Silver Diamine Fluoride (SDF) is a more conservative and effective treatment in preventing the progression of mild occlusal caries compared to fissure sealant in patients aged 20-45 years with incipient molar caries. The main question it aims to answer is: Is SDF more effective in arresting caries progression than fissure sealant? Does SDF prevent the formation of new caries compared to fissure sealant? Researchers will compare SDF treatment to fissure sealant application to see if SDF results in better caries arrest and fewer new carious lesions. Participants will: Be randomly assigned to receive either SDF or fissure sealant. Have follow-up assessments at 1, 3, 6, and 12 months for caries progression, arrest, and new caries formation. Undergo clinical evaluations using visual and tactile examinations to assess caries arrest and progression and using DIAGNOdent laser fluorescence system .
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06861725
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other trials of Silver Diamine Fluoride (SDF)
Trials testing the same drug.
- NCT07326241 — Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars · NA · not yet recruiting
- NCT05872542 — SDF Effectiveness on Arresting Caries in Children · Phase 4 · recruiting
- NCT04642846 — Clinical and Laboratory Assessments of Effectiveness of Silver Diamine Fluoride (SDF) in Arresting Caries Among Children · NA · unknown
Other recruiting trials for Dental Caries
Currently open trials in the same condition.
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- NCT07134114 — Occlusal Impact of Hall Crowns in Primary Molars · NA · recruiting
- NCT07181967 — SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children · NA · recruiting
Other Cairo University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06861725 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cairo University
- Last refreshed: 6 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06861725.
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