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NCT07326241
Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars
NA trial testing Standard Local Anesthesia in MIH in 75 participants. Not yet recruiting.
15 March 2026
Quick facts
| Lead sponsor | Çanakkale Onsekiz Mart University |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 75 |
| Start date | 1 February 2026 |
| Primary completion | 15 March 2026 |
| Estimated completion | 1 April 2026 |
| Sites | 2 locations across Turkey (Türkiye) |
Drugs / interventions tested
- Standard Local Anesthesia
- Intraoral Cryotherapy
- Silver Diamine Fluoride (SDF) — full drug profile →
Conditions studied
- MIH — all drugs for MIH →
- Molar-Incisor Hypomineralization — all drugs for Molar-Incisor Hypomineralization →
- Caries Assessment — all drugs for Caries Assessment →
Sponsor
Çanakkale Onsekiz Mart University
Who can join
Adults 6 to 12, any sex, with MIH or Molar-Incisor Hypomineralization. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Molar-incisor hypomineralization (MIH) is a developmental enamel defect of unclear etiology that affects permanent first molars and often permanent incisors, leading to increased porosity, hypersensitivity, and poor prognosis. The porous structure of MIH-affected enamel facilitates bacterial penetration, which may cause subclinical pulpal inflammation and reduce the effectiveness of local anesthesia during dental procedures. Achieving adequate anesthesia in children with MIH can be challenging, resulting in increased discomfort, anxiety, and behavioral management difficulties. Cryotherapy has been shown to reduce pain by decreasing local inflammation and slowing nerve conduction, while silver diamine fluoride (SDF) has demonstrated efficacy in reducing dentin hypersensitivity through tubule occlusion, antibacterial activity, and remineralization. This study aims to evaluate the effects of intraoral cryotherapy and silver diamine fluoride application on pain perception and the efficacy of local anesthesia during operative dental procedures in MIH-affected permanent first molars.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07326241
- Europe PMC full search
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07326241 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Çanakkale Onsekiz Mart University
- Last refreshed: 8 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07326241.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing