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NCT06834711
Chlorhexidine Versus N-Asetil Sistein Irrigation in Mandibular Molar Teeth with Chronic Apical Periodontitis
NA trial testing N-Acetyl Cysteine in Chronic Apical Periodontitis in 78 participants. Completed in 5 January 2025.
12 December 2024
Quick facts
| Lead sponsor | Cukurova University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 78 |
| Start date | 15 February 2024 |
| Primary completion | 12 December 2024 |
| Estimated completion | 5 January 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- N-Acetyl Cysteine
- Chlorhexidine (CHLORHEXIDINE) — full drug profile →
Conditions studied
- Chronic Apical Periodontitis — all drugs for Chronic Apical Periodontitis →
Sponsor
Cukurova University
Who can join
Adults 18 to 55, any sex, with Chronic Apical Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical study was to evaluate the effect of using different irrigation solutions in the final irrigation of root canal treatment procedures on the intensity of postoperative pain and periapical tissue healing in patients presenting with mandibular molars with chronic apical periodontitis. The main question it aims to answer is: \- Does controlled irrigation with chlorhexidin and N-asetil sistein in root canal treatment reduce the severity of postoperative pain? In the chlorhexidin group, unlike the control group, each root canal was irrigated with 3 mL %2 chlorhexidin solution in the final irrigation. In the N-asetil sistein group, unlike the control group, each root canal was irrigated with 3 mL 200 mg/ml N-asetil sistein solution in the final irrigation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06834711
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of N-Acetyl Cysteine
Trials testing the same drug.
- NCT07391163 — Protective Effect of N-acetylcysteine on Oxaliplatin-Induced Neuropathy in Colorectal Cancer · NA · completed
- NCT04291209 — Intratympanic N-Acetylcysteine for Prevention of Cisplatin-induced Ototoxicity. · Phase 1, PHASE2 · unknown
- NCT03759158 — N-Acetyl Cysteine in the Prevention of Contrast Induced Nephropathy in Cirrhosis of Liver-NEPHRO Trial · NA · completed
- NCT03364218 — Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use · Phase 4 · unknown
Other recruiting trials for Chronic Apical Periodontitis
Currently open trials in the same condition.
- NCT07388901 — In Vivo Study on the Material Properties of iRoot SP and nRoot SP Root Canal Sealers · NA · recruiting
- NCT07069881 — Sonic vs Passive Ultrasonic Irrigation for Chronic Apical Periodontitis · NA · recruiting
- NCT07059481 — Effect of Different Root Canal Sealers on Oxidative Stress Markers · NA · recruiting
Other Cukurova University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06834711 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cukurova University
- Last refreshed: 20 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06834711.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing