NCT06830200

Peri-implantitis Treatment With Chitosan Brush

Recruiting now NA Last updated 15 September 2025

What this trial tests

NA trial testing Non-surgical periodontal treatment with chitosan brush in Peri-implantitis in 60 participants. Currently enrolling.

Timeline

10 April 2025

Primary endpoint
1 December 2026

1 June 2027

Quick facts

Lead sponsor	Hacettepe University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	10 April 2025
Primary completion	1 December 2026
Estimated completion	1 June 2027
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Non-surgical periodontal treatment with chitosan brush
• Non-surgical treatment of pre-implantitis with titanium curette

Conditions studied

• Peri-implantitis — all drugs for Peri-implantitis →

Sponsor

Hacettepe University

Who can join

Adults 18 to 65, any sex, with Peri-implantitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In dentistry, dental implant applications for tooth loss/deficiency are prominent and provide successful long-term results in terms of functionality and aesthetics. However, peri-implant diseases such as peri-implant mucositis and peri-implantitis may develop due to biofilm accumulation around the implant. In peri-implantitis, in addition to the clinical inflammation findings seen in peri-implant mucositis, there is also progressive bone loss. This condition is to be treated with non-surgical or surgical methods. Titanium curettes, ultrasonic instruments, laser systems, and chitosan brushes are used for biofilm removal in non-surgical treatment. Chitosan is a natural polysaccharide obtained from chitin. It is biocompatible, biodegradable, and has antibacterial activity. In addition, chitosan reduces the levels of IL-1β, IL-6, and TNF-α, which also play a role in the pathogenesis of peri-implantitis, and exhibits anti-inflammatory effects on macrophages activated by lipopolysaccharide. Although many methods are used to treat peri-implantitis, successful and predictable results cannot be obtained. This study aims to examine the clinical and immunological findings and observe the changes in the non-surgical treatment of peri-implantitis using chitosan brush or titanium curette over 12 months. Sixty dental implants diagnosed with peri-implantitis clinically and radiographically at the Department of Periodontics, Faculty of Dentistry, Hacettepe University will be included in the study. Non-surgical peri-implantitis treatment of these patients will be performed using a chitosan brush (N=30, case group) or titanium curette (N=30, control group). Pre-operative and post-operative 3rd, 6th, and 12th months, clinical periodontal indices will be recorded, peri-implant crevicular fluid (PIF) will be collected, and maintenance treatment will be applied to the patients. IL-1β, TNF-α, IL-8, IL-10, and IL-17 levels in the collected PIF will be determined by the ELISA method. The effectiveness of chitosan brush and titanium curette in treating peri-implantitis will be evaluated and compared clinically and immunologically.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.