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NCT06820996
Effect of Cryotreated Sodium Hypochlorite Irrigation at Different Consentrations in Mandibular First Molars
NA trial testing Cryotherapy in Pulpitis - Irreversible in 132 participants. Completed in 15 January 2025.
18 November 2024
Quick facts
| Lead sponsor | Cukurova University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 132 |
| Start date | 18 March 2024 |
| Primary completion | 18 November 2024 |
| Estimated completion | 15 January 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Cryotherapy (CRYOTHERAPY) — full drug profile →
- Control (Standard treatment) — full drug profile →
Conditions studied
- Pulpitis - Irreversible — all drugs for Pulpitis - Irreversible →
Sponsor
Cukurova University
Who can join
Adults 18 to 65, any sex, with Pulpitis - Irreversible. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial was to evaluate the effect of cryotreated sodium hypochlorite solution on the intensity of postoperative pain in root canal treatment procedures in mandibular first molar teeth with symptomatic irreversible pulpitis. The main question it aims to answer is: \- Does controlled irrigation with cold sodium hypochlorite in root canal treatment reduce the severity of postoperative pain? In the cryotreated NaOCl group, unlike the normal NaOCl group, the root canals were irrigated with 2 °C NaOCl solution.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The effect of cryotreated sodium hypochlorite irrigation at different concentrations on postoperative pain in mandibular first molars with symptomatic irreversible pulpitis: a randomized controlled clinical trial.
Gürler K, Yilmaz K. · · 2025 · PMID 41291644 · DOI 10.1186/s12903-025-07410-3
Verify or expand the search:
- PubMed search for NCT06820996
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other recruiting trials for Pulpitis - Irreversible
Currently open trials in the same condition.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06820996 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cukurova University
- Last refreshed: 14 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06820996.
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