NCT06816329

Stress Dynamics and Familial Risk for Depression in Female Adolescents

Recruiting now NA Last updated 23 October 2025

What this trial tests

NA trial testing Computer Task Manipulation in Major Depressive Disorder in 148 participants. Currently enrolling.

Timeline

15 October 2025

Primary endpoint
31 March 2030

31 March 2030

Quick facts

Lead sponsor	Mclean Hospital
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	148
Start date	15 October 2025
Primary completion	31 March 2030
Estimated completion	31 March 2030
Sites	1 location across United States

Drugs / interventions tested

• Computer Task Manipulation

Conditions studied

• Major Depressive Disorder — all drugs for Major Depressive Disorder →

Sponsor

Mclean Hospital

Who can join

Adults 13 to 15, female only, with Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Stress and a parental history of major depressive disorder (MDD) are among the strongest risk factors for future development of MDD. Studies have shown that having a parental history of MDD may be associated with behavioral, psychophysiological, and hormonal responses to stress that are associated with poorer stress coping. . Adolescence is a vulnerable developmental window linked to increased MDD risk, especially for females, as rates of MDD surge relative to males. Despite the central role of stress in MDD onset, little is known about the brain mechanisms underlying stress responses in susceptible female adolescents at high familial risk for MDD. Also, it is unclear how stress-related brain network alterations may relate to "real-world" maladaptive stress responses and whether these stress-related brain network changes are predictive of future depression onset. We will fulfill these research gaps by combining neuroimaging with intensive longitudinal tracking of depressive symptomology as well as behavioral and physiological responses to "real world" stress using smartphone and smartwatch technology. Elucidating these neural mechanisms may aid in the discovery of MDD biomarkers that could identify youth at greatest risk for future MDD development and lead to earlier intervention efforts.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.