NCT06811961

Effects of Exercise in Patients with Lipedema

Recruiting now NA Last updated 6 February 2025

What this trial tests

NA trial testing Exercise in Lipedema in 20 participants. Currently enrolling.

Timeline

5 October 2024

Primary endpoint
5 February 2025

5 February 2025

Quick facts

Lead sponsor	Ilke Keser
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	20
Start date	5 October 2024
Primary completion	5 February 2025
Estimated completion	5 February 2025
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Exercise
• Physical activity

Conditions studied

• Lipedema — all drugs for Lipedema →

Sponsor

Ilke Keser

Who can join

18 and older, female only, with Lipedema. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Lipedema is a chronic progressive disease characterized by symmetrical, disproportionate swelling of subcutaneous adipose tissue, which is common in women and mostly seen in the lower extremities and to a lesser extent in the upper extremities. Healthy lifestyle approaches including exercise treatments are very important for lipedema patients in order to prevent disease progression. The aim of this study is to investigate the effects of exercise on edema, pain, exercise capacity, lower extremity muscle strength and function in lipedema patients. Sociodemographic information of the patients, body composition with Tanita InnerScan BC-601-CG device, clinical information regarding lipedema, type and stage of lipedema, inspection, palpation findings will be recorded. Local tissue water percentage will be assessed using Moisturemeter-d compact (MMDc, Delfin Technologies, Kuopio, Finland) device, circumference measurement using tape, pain intensity with Visual Analog Scale, pain threshold with Baseline brand digital algometer device. Muscle strength will be assessed using K-Force hand dynamometer. Functional exercise capacity will be assessed with the 6-minute walk test (6MWT), and lower extremity dysfunction with the lower extremity functional scale. After the assessments are made, the patients will be randomly divided into 2 groups. The patients in the study group will perform group exercises consisting of warm-up, loading and cool-down periods of 40-50 minutes, 2 days a week for 6 weeks, and strengthening exercises applied to the hip muscles and knee extensors with elastic resistance bands, which are decided according to the level of effort perceived by the patient, 3 sets of 10 repetitions, 2 days a week for 6 weeks. The same assessments will be applied to the patients again at the end of the exercise program. The control group will be re-evaluated after 6 weeks with suggestions regarding lipedema and physical activity level, and the obtained data will be compared.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effects of multimodal exercise program on edema, pain, exercise capacity, lower extremity muscle strength and function in patients with lipedema.
   Sakizli Erdal E, Ergin C, Haspolat M, Erturk B, et al · · 2026 · cited 1× · PMID 40372970 · DOI 10.1177/02683555251343148