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NCT06806033
A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma
Phase 2 trial testing Obinutuzumab in B-Cell Non-Hodgkins Lymphoma in 100 participants. Currently enrolling.
31 January 2027
Quick facts
| Lead sponsor | Hoffmann-La Roche |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 5 March 2025 |
| Primary completion | 31 January 2027 |
| Estimated completion | 30 March 2029 |
| Sites | 51 locations across France, Italy, Germany, South Korea, Canada, Australia, United States |
Drugs / interventions tested
- Obinutuzumab — full drug profile →
- Glofitamab (glofitamab) — full drug profile →
- Gemcitabine (gemcitabine) — full drug profile →
- Oxaliplatin (Oxaliplatin) — full drug profile →
Conditions studied
- B-Cell Non-Hodgkins Lymphoma — all drugs for B-Cell Non-Hodgkins Lymphoma →
Sponsor
Hoffmann-La Roche — full company profile →
Who can join
18 and older, any sex, with B-Cell Non-Hodgkins Lymphoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This Phase II trial evaluates the optimization of the cytokine release syndrome (CRS) profile for glofitamab in combination with gemcitabine and oxaliplatin (Glofit-GemOx) in participants with relapsed or refractory aggressive B-cell Non-Hodgkin's lymphoma. The study utilizes an optimized steroid premedication regimen and monitoring schedule specifically designed to enable the administration of the treatment regimen in an outpatient setting.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06806033
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Other Hoffmann-La Roche trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06806033 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hoffmann-La Roche
- Last refreshed: 31 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06806033.
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