Last reviewed 2026-04-20 · How we verify

Columvi (glofitamab)

Columvi works by binding to the CD20 protein on B-cell lymphoma cells, triggering an immune response to destroy the cancer cells.

At a glance

Mechanism of action

Glofitamab-gxbm is bispecific antibody that binds to CD20 expressed on the surface of cells, and to CD3 receptor expressed on the surface of cells. Glofitamab-gxbm causes T-cell activation and proliferation, secretion of cytokines, and the lysis of CD20-expressing cells. Glofitamab-gxbm showed anti-tumor activity in vivo in mouse models of DLBCL.

Approved indications

• Relapsed or refractory diffuse large B-cell lymphoma

Boxed warnings

• WARNING: CYTOKINE RELEASE SYNDROME Cytokine Release Syndrome (CRS), including serious or fatal reactions, can occur in patients receiving COLUMVI. Premedicate before each dose, and initiate treatment with the COLUMVI step-up dosing schedule to reduce the risk of CRS. Withhold COLUMVI until CRS resolves or permanently discontinue based on severity [see Dosage and Administration (2.1 , 2.2 , 2.3 , and 2.4) and Warnings and Precautions (5.1) ] . WARNING: CYTOKINE RELEASE SYNDROME See full prescribing information for complete boxed warning Cytokine Release Syndrome (CRS), including serious or fatal reactions, can occur in patients receiving COLUMVI. Premedicate before each dose, and initiate treatment with the COLUMVI step-up dosing schedule to reduce the risk of CRS. Withhold COLUMVI until CRS resolves or permanently discontinue based on severity. ( 2.1 , 2.2 , 2.3 , 2.4 , 5.1 )

Common side effects

• Cytokine release syndrome
• Musculoskeletal pain
• Rash
• Fatigue
• Lymphocyte count decreased
• Phosphate decreased
• Neutrophil count decreased
• Uric acid increased
• Fibrinogen decreased
• Pyrexia
• Edema
• Constipation

Key clinical trials

• Testing the Addition of an Anti-Cancer Drug, Glofitamab, to the Usual Chemotherapy Treatment (Alternating R-CHOP/R-DHAP) for Previously Untreated Mantle Cell Lymphoma (PHASE1)
• Gut Microbiome in DLBCL Treated With Glofitamab
• Glofitamab in Chinese Patients With R/R DLBCL
• A Study of Glofitamab and Lenalidomide in People With Mantle Cell Lymphoma (PHASE1)
• A Study to Learn About the Effects of Two Study Medicines (Maplirpacept [PF-07901801] And Glofitamab) When Given Together In People With Relapsed Or Refractory Diffuse Large B Cell Lymphoma. (PHASE1,PHASE2)
• Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy (PHASE2)
• A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma (PHASE1)
• Efficacy and Safety of Glofitamab Combined With GemOxin the Treatment of Refractory Diffuse Large B-Cell Lymphoma (PHASE2)

Primary sources

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