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NCT06800183
Topical Application of Tartrazine for Enhanced Visualization of Subcutaneous Structures in Dermatology
EARLY_PHASE1 trial testing Four-Chamber Tartrazine Patch across 3 Body Sites in Healthy. Withdrawn.
1 December 2026
Quick facts
| Lead sponsor | Johns Hopkins University |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Start date | 11 May 2026 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Four-Chamber Tartrazine Patch across 3 Body Sites — full drug profile →
Conditions studied
- Healthy — all drugs for Healthy →
- Dermoscopy — all drugs for Dermoscopy →
- Optical Imaging — all drugs for Optical Imaging →
Sponsor
Johns Hopkins University
Who can join
Adults 18 to 65, any sex, with Healthy or Dermoscopy. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Optical Transparency as Assessed by Total Transmittance Percentage
Time frame: Up to 90 minutes
To determine the optimal duration for maximum transparency, serial imaging will be conducted over the course of one 90 minute clinic visit (baseline, immediately post-application, and at 5-minute intervals until transparency plateaus). Imaging will be performed using non-invasive modalities. High-resolution dermoscopy will capture clear images of skin structures, and standardized high-quality phot
Sponsor's own description
The goal of this clinical trial is to learn if the topical application of tartrazine, an FDA-approved food dye, can help improve the transparency of the skin in healthy volunteers. The main questions it aims to answer are: * Can topical tartrazine application allow for temporary skin transparency? * What dose of tartrazine is required to achieve reversible skin transparency? Participants will: * Be given a patch test with four different doses of tartrazine * Have these patch tests placed on the back, stomach, and forearm * Have photographs taken every 5 minutes to see if transparency is achieved * Be called 48 hours later to check for any side effects
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06800183
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06800183 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
- Last refreshed: 13 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06800183.
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