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NCT06760312
Effect of Different Apical Actions on Local Inflammatory Mediators and Pain
NA trial testing Root canal shaping with Continuous Rotation in Postoperative Dental Pain in 75 participants. Completed in 1 July 2025.
1 May 2025
Quick facts
| Lead sponsor | Izmir Katip Celebi University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 75 |
| Start date | 1 February 2024 |
| Primary completion | 1 May 2025 |
| Estimated completion | 1 July 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Root canal shaping with Continuous Rotation
- Root canal shaping with Apical Reverse
- Root canal shaping is conducted with Apical slow-down kinematic.
Conditions studied
- Postoperative Dental Pain — all drugs for Postoperative Dental Pain →
- Pulp Disease, Dental — all drugs for Pulp Disease, Dental →
- Pulpitis - Irreversible — all drugs for Pulpitis - Irreversible →
Sponsor
Izmir Katip Celebi University
Who can join
Adults 18 to 49, any sex, with Postoperative Dental Pain or Pulp Disease, Dental. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to determine patients' the inflammation and pain response to different apical actions used in rotary instrumentation during root canal shaping process. The main questions it aims to answer are: 1. How the different apical actions of endodontic motors influence the pain and inflammatory mediator release from the periapical region of related tooth? 2. Does the perceived pain differ among the used apical action methods after the root canal preparation? 3. Are the perceived pain and local pain mediator levels coherent? Participants will: Attend to the root canal treatment in the endodontics clinic. The treatment will be two visits. Answer the Visual Analog Scale questionnaire on day 0 (first appt.) and Day 3 (second appt.) Keep a diary of their symptoms and the number of times they use an anti-inflammatory drug.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06760312
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06760312 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Izmir Katip Celebi University
- Last refreshed: 16 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06760312.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing