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NCT06749483: MS-ICU
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
trial in Critical Illness in 100 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | Jena University Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 27 December 2024 |
| Primary completion | 30 June 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Germany |
Conditions studied
- Critical Illness — all drugs for Critical Illness →
- Intensive Care Unit Delirium — all drugs for Intensive Care Unit Delirium →
- Neurocognitive Deficit — all drugs for Neurocognitive Deficit →
- Microbiome,immune Function, Critically Ill — all drugs for Microbiome,immune Function, Critically Ill →
Sponsor
Jena University Hospital
Who can join
18 and older, any sex, with Critical Illness or Intensive Care Unit Delirium. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis. The proposal aims to combine holistic approaches with emerging experimental technologies to investigate the complex interactions between the gut microbiota and its host and assess the impact of specific bacterial communities on longevity and stress responses. A strong focus of this study will also be placed on microbiome dysbiosis and secondary impacts on short- and long-term brain dysfunction using clinical, laboratory and imaging procedures.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Correlation of brain injury biomarkers with brain dysfunction, brain injury, and outcomes in critically ill patients: a post hoc exploratory analysis.
Rühlmann M, Xu L, Bauer M, Lehmann T, et al · · 2026 · PMID 41973367 · DOI 10.1007/s15010-026-02790-2 -
Role of the intestinal microbiota in sepsis-associated encephalopathy.
Zhang M, Xiao D, He T, Guo L, et al · · 2026 · PMID 41560867 · DOI 10.1093/burnst/tkaf070
Verify or expand the search:
- PubMed search for NCT06749483
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06749483 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Jena University Hospital
- Last refreshed: 30 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06749483.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing