NCT06715709 (DEXA_PERIOP) is a Phase 4 clinical trial of Dexamethasone IV in Arthropathy of Knee, sponsored by Mayo Clinic.

Who is sponsoring NCT06715709?

NCT06715709 is sponsored by Mayo Clinic.

What drugs are being tested in NCT06715709?

Interventions in NCT06715709: Dexamethasone IV, Dexamethasone IV+Oral, Dexamethasone IV+Oral 2 Day.

What condition does NCT06715709 study?

NCT06715709 studies Arthropathy of Knee.

Is NCT06715709 still recruiting?

NCT06715709 is currently enrolling by invitation. Last updated 6 February 2026.

Last reviewed 2026-02-06 · How we verify

NCT06715709: DEXA_PERIOP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

How Many Dexamethasone Doses Should Be Given Perioperatively?

ENROLLING BY INVITATION Phase 4 Last updated 6 February 2026

What this trial tests

Phase 4 trial testing Dexamethasone IV in Arthropathy of Knee in 339 participants. Enrolling by invitation.

Timeline

25 March 2025

Primary endpoint
1 January 2027

1 January 2027

Quick facts

Lead sponsor	Mayo Clinic
Phase	Phase 4
Status	ENROLLING BY INVITATION
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	339
Start date	25 March 2025
Primary completion	1 January 2027
Estimated completion	1 January 2027
Sites	1 location across United States

Drugs / interventions tested

Dexamethasone IV
Dexamethasone IV+Oral — full drug profile →
Dexamethasone IV+Oral 2 Day — full drug profile →

Conditions studied

Arthropathy of Knee — all drugs for Arthropathy of Knee →

Sponsor

Mayo Clinic

Who can join

18 and older, any sex, with Arthropathy of Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine the most efficient and safest dexamethasone dose given perioperatively during total knee arthroplasty that reduces postoperative option consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Dexamethasone IV

Trials testing the same drug.

NCT05704049 — A Study to Investigate Subcutaneous Isatuximab in Combination With Carfilzomib and Dexamethasone in Adult Participants W · Phase 2 · active not recruiting

Other recruiting trials for Arthropathy of Knee

Currently open trials in the same condition.

NCT07180953 — Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty · Phase 4 · recruiting
NCT05290818 — Total Versus Robotic Assisted Unicompartmental Knee Replacement · NA · recruiting
NCT06832995 — Incidence and Risk Factors for Post-Anesthetic Morphine Titration in Recovery Room After Hip and Knee Arthroplasties · active not recruiting
NCT03869996 — Total Knee Arthroplasty: Fast Track Protocol is the Future? · NA · recruiting
NCT03674697 — The Effect of Light Therapy on Post-Surgical Pain · NA · active not recruiting

Other Mayo Clinic trials

Trials by the same sponsor.

NCT07126548 — A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men · NA · not yet recruiting
NCT07221656 — Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration · not yet recruiting
NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06715709 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
Last refreshed: 6 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06715709.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing