NCT06706414 (NT-NOA) is a Phase 1/Phase 2 clinical trial of Denosumab (Prolia) in Infertility, Male, sponsored by Martin Blomberg Jensen.

Who is sponsoring NCT06706414?

NCT06706414 is sponsored by Martin Blomberg Jensen.

What drugs are being tested in NCT06706414?

Interventions in NCT06706414: Denosumab (Prolia), Letrozole (Aromatase Inhibitors).

What condition does NCT06706414 study?

NCT06706414 studies Infertility, Male.

Is NCT06706414 still recruiting?

NCT06706414 is currently active, enrolled. Last updated 16 April 2026.

Last reviewed 2026-04-16 · How we verify

NCT06706414: NT-NOA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Novel Treatment of Some Men With Non-Obstructive Azoospermia (NT-NOA): A Clinical Interventional Study

Active, enrolled Phase 1/Phase 2 Last updated 16 April 2026

What this trial tests

Phase 1/Phase 2 trial testing Denosumab (Prolia) in Infertility, Male in 16 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 March 2025

Primary endpoint
1 August 2026

1 August 2026

Quick facts

Lead sponsor	Martin Blomberg Jensen
Phase	Phase 1/Phase 2
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	16
Start date	1 March 2025
Primary completion	1 August 2026
Estimated completion	1 August 2026
Sites	1 location across Denmark

Drugs / interventions tested

Denosumab (Prolia) — full drug profile →
Letrozole (Aromatase Inhibitors) — full drug profile →

Conditions studied

Infertility, Male — all drugs for Infertility, Male →

Sponsor

Martin Blomberg Jensen — full company profile →

Who can join

Adults 18 to 60, male only, with Infertility, Male. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Sperm in the semen sample or TESE on day 90
Time frame: Day 80 (semen sample) and 90 (TESE) after inclusion
Finding of sperm in the semen sample (day 80) or TESE (day 90), that subsequently will be compared with prior TESE if available.

Sponsor's own description

This clinical interventional study aims to assess whether treatment with denosumab in combination with letrozole can improve sperm production in infertile men with non-obstructive azoospermia selected by serum anti-mullerian hormone (AMH) as a positive predictive biomarker.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Denosumab (Prolia)

Trials testing the same drug.

NCT07056478 — RANKL Inhibition to Combat Sarcopenia in Hip Fracture Patients · Phase 3 · not yet recruiting
NCT06720350 — Efficacy of Romosozumab and Denosumab Combined Treatment in Postmenopausal Osteoporosis Patients with Multiple Fragility · Phase 4 · not yet recruiting
NCT03029442 — The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury · Phase 4 · terminated

Other recruiting trials for Infertility, Male

Currently open trials in the same condition.

NCT06950203 — The Effect of Supplementation With Fish Oil (EPAX EVOLVE 05) on Sperm Quality · NA · recruiting
NCT06539585 — Scanning the Meiotic Spindle in Assisted Reproductive Techniques to Assess Oocyte Quality · NA · active not recruiting
NCT05514223 — Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors · recruiting
NCT06841861 — Spermatogonial Differentiation Via Testicular Organoid · Phase 1, PHASE2 · recruiting
NCT05903859 — Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI) · Phase 3 · recruiting

Other Martin Blomberg Jensen trials

Trials by the same sponsor.

NCT06300229 — NAPO - Novel Approach for Oligospermia · Phase 1, PHASE2 · completed
NCT05212337 — FITMI - First In Treating Male Infertility · Phase 2 · active not recruiting
NCT04292288 — Hypercalcemia After Paraffin Oil Injection · recruiting
NCT03418896 — Extragonadal Effects of hCG on Calcium Homeostasis · Phase 1 · completed
NCT03254641 — Calciotropic Effects After HCG Stimulation Test · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06706414 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Martin Blomberg Jensen
Last refreshed: 16 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06706414.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing