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NCT06701500: ReCoDe
Assessing Habitual, Goal-Directed, and Pavlovian Influences in Alcohol Use Disorder
trial testing Pavlovian-to-instrumental transfer (PIT) paradigm in Alcohol Use Disorder (AUD) in 180 participants. Currently enrolling.
31 March 2025
Quick facts
| Lead sponsor | Technische Universität Dresden |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 180 |
| Start date | 2 March 2024 |
| Primary completion | 31 March 2025 |
| Estimated completion | 30 June 2027 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Pavlovian-to-instrumental transfer (PIT) paradigm
- Action Sequence Task (AST)
- Basic psychological assessment (interview)
- Basic psychological assessment (questionnaires)
- Neuropsychology tests
Conditions studied
- Alcohol Use Disorder (AUD) — all drugs for Alcohol Use Disorder (AUD) →
- Alcoholism — all drugs for Alcoholism →
- Substance Use Disorders — all drugs for Substance Use Disorders →
Sponsor
Technische Universität Dresden — full company profile →
Who can join
Adults 18 to 65, any sex, with Alcohol Use Disorder (AUD) or Alcoholism. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The first aim of this study is to establish the role of maladaptive reliance on habits for impaired control in addiction, employing a novel task - the Action-Sequence-Task (AST), which assesses interference between habitual and goal-directed control. The AST, along with the developed computational model, will be employed to test whether participants with Alcohol Use Disorder (AUD) and control participants differ with respect to task performance and estimated model parameters. The investigators hypothesize stronger habitual behavior (increased habitual tendency) and an increased susceptibility to conflict between habitual and goal-directed control, measured as increased interference, are associated with AUD. The second aim of the study is to understand whether Pavlovian-to-Instrumental Transfer (PIT) reflects more of a controlled, goal-directed process, or a more automatic, habitual process. The investigators will use the single-lever PIT task as it is an efficient tool for testing the interaction between Pavlovian cues and instrumental behavior, especially when they are in conflict. In these trials, top-down control must be allocated to successfully overcome the conflict, which may share some common underlying mechanisms with the arbitration between goal-directed and habitual behavior during conflict, as assessed by the novel AST. The third aim of the study is to investigate whether severely dependent AUD patients would show a stronger PIT effect compared to a control group, consistent with the investigators' previous findings.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06701500
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Related trials
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Trials testing the same drug.
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Other Technische Universität Dresden trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06701500 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Technische Universität Dresden
- Last refreshed: 22 November 2024
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