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NCT06685991: TIDE
Effect of Timing of Dexamethasone During Induction on Postoperative Outcomes
Phase 4 trial testing Dexamethasone in Postoperative Nausea and Vomiting (PONV) in 300 participants. Not yet recruiting.
31 December 2025
Quick facts
| Lead sponsor | AABDI Mohammed |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 300 |
| Start date | 1 December 2024 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 January 2026 |
Drugs / interventions tested
- Dexamethasone (dexamethasone) — full drug profile →
Conditions studied
- Postoperative Nausea and Vomiting (PONV) — all drugs for Postoperative Nausea and Vomiting (PONV) →
- Postoperative Pain — all drugs for Postoperative Pain →
- Inflammatory Response to Wounding — all drugs for Inflammatory Response to Wounding →
- Hyperglycemia Drug Induced — all drugs for Hyperglycemia Drug Induced →
Sponsor
AABDI Mohammed
Who can join
Adults 18 to 70, any sex, with Postoperative Nausea and Vomiting (PONV) or Postoperative Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to investigate how the timing of dexamethasone administration during anesthesia induction affects patient outcomes after surgery. Dexamethasone is commonly used to reduce nausea and inflammation during and after surgery. However, it is not yet known if administering dexamethasone at different times during induction (before, during, or after specific anesthetic drugs) leads to better recovery and fewer postoperative complications. Participants will be randomly assigned to one of three groups: one group will receive dexamethasone before fentanyl, another after the muscle relaxant, and a third group will not receive dexamethasone. This approach will help us understand if the timing of dexamethasone affects patient outcomes such as nausea, pain, and recovery quality. The study is triple-blinded, meaning that the participants, care providers, and investigators will not know which group the participants are in, to ensure unbiased results.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06685991
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Dexamethasone
Trials testing the same drug.
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- NCT07513129 — A Phase 1 Study Of Venetoclax, Dexamethasone, Bortezomib, And Daratumumab (VDBD) For Adolescent And Young Adult Patients · Phase 1 · not yet recruiting
- NCT07444710 — Testing the Addition of an Anti-Cancer Drug, Glofitamab, to the Usual Chemotherapy Treatment (Alternating R-CHOP/R-DHAP) · Phase 1 · not yet recruiting
- NCT07387926 — Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+ · Phase 1, PHASE2 · not yet recruiting
Other recruiting trials for Postoperative Nausea and Vomiting (PONV)
Currently open trials in the same condition.
- NCT07440667 — Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section · NA · recruiting
- NCT07488468 — Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures · recruiting
- NCT07534956 — The Effect of Paedfusor TCI, Eleveld TCI, and Sevoflurane Anesthesia on Postoperative Awakening Agitation in Pediatric P · NA · recruiting
- NCT07148063 — Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy · recruiting
- NCT07201883 — Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients · Phase 1 · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06685991 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by AABDI Mohammed
- Last refreshed: 13 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06685991.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing