NCT06653465 is a Phase 2/Phase 3 clinical trial of Acetaminophen in Delirium in Old Age, sponsored by RenJi Hospital.

Who is sponsoring NCT06653465?

NCT06653465 is sponsored by RenJi Hospital.

What drugs are being tested in NCT06653465?

Interventions in NCT06653465: Acetaminophen, Saline.

What condition does NCT06653465 study?

NCT06653465 studies Delirium in Old Age.

Is NCT06653465 still recruiting?

NCT06653465 is currently not yet recruiting. Last updated 1 April 2025.

Last reviewed 2025-04-01 · How we verify

NCT06653465

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery: a Randomised Controlled Study

Not yet recruiting Phase 2/Phase 3 Last updated 1 April 2025

What this trial tests

Phase 2/Phase 3 trial testing Acetaminophen in Delirium in Old Age in 1,930 participants. Not yet recruiting.

Timeline

1 June 2025

Primary endpoint
1 June 2027

1 July 2027

Quick facts

Lead sponsor	RenJi Hospital
Phase	Phase 2/Phase 3
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	1,930
Start date	1 June 2025
Primary completion	1 June 2027
Estimated completion	1 July 2027

Drugs / interventions tested

Acetaminophen (Paracetamol) — full drug profile →
Saline

Conditions studied

Delirium in Old Age — all drugs for Delirium in Old Age →

Sponsor

RenJi Hospital

Who can join

65 and older, any sex, with Delirium in Old Age. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Incidence of postoperative delirium
Time frame: Participants will be followed up during the first 5 postoperative days.
Delirium will be assessed by the trained investigators twice daily, from 8-10 AM and from 5-7 PM, starting from postoperative day 1 using 3-minute Confusion Assessment Method (3D-CAM) or CAM-ICU for intubated patients. Immediately before assessing delirium, sedation or agitation was assessed using Richmond Agitation-Sedation Scale (RASS). If the patient was too deeply sedated or unarousable (RASS

Sponsor's own description

Investigators propose this multi-center randomised controlled study to test the preventive effect of intravenouse acetaminophen in delirium over 5 postoperative days among older patients recovering from major non-cardiac surgery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Intravenous acetaminophen for postoperative delirium in older patients recovering from major non-cardiac surgery: a randomised-controlled study protocol.
Zheng M, Wang B, Mao M, Wu Y, et al · · 2025 · PMID 40379334 · DOI 10.1136/bmjopen-2024-097079

Verify or expand the search:

Other trials of Acetaminophen

Trials testing the same drug.

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NCT06994442 — Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · recruiting
NCT07101445 — Evaluating Premedication Regimens (Methylprednisolone vs Dexamethasone-based) for the Prevention of Systemic and Injecti · Phase 4 · recruiting

Other recruiting trials for Delirium in Old Age

Currently open trials in the same condition.

NCT06721819 — The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium · Phase 3 · recruiting
NCT06216483 — Using EMR Data and AI to Develop a Passive Digital Marker to Predict Postoperative Delirium · NA · active not recruiting
NCT06100029 — The Effect of Lavender Essential Oil for Delirium in Elderly Intensive Care Unit Patients: Study Protocol · NA · recruiting
NCT05242419 — A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery · NA · recruiting

Other RenJi Hospital trials

Trials by the same sponsor.

NCT07584733 — Biomarker-Enriched Kidney-Preserving Strategy With Disitamab Vedotin Plus Tislelizumab in HER2-Positive High-Risk Upper · Phase 2 · not yet recruiting
NCT07537725 — EEG-TMS for Postoperative Delirium After Cardiac Surgery · NA · not yet recruiting
NCT07527936 — A Study of BEN301 Injection in theTreatment of Autoimmune Diseases · EARLY_PHASE1 · not yet recruiting
NCT07343076 — Efficacy of Immediate Versus Staged Complete Revascularization in Patients With NSTE-ACS and Multivessel Disease (FUTURE · NA · not yet recruiting
NCT07449793 — Biochemical Response and Clinical Outcomes in Patients With PBC · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06653465 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by RenJi Hospital
Last refreshed: 1 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06653465.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing