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NCT06646705
Biochemical Evaluation of Periodontal Effects of Orthodontic Treatment with Aligners
NA trial testing Saliva obtaining in Aligner Treatment in 25 participants. Participants enrolled and being followed up; not accepting new ones.
30 October 2024
Quick facts
| Lead sponsor | Izmir Katip Celebi University |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 25 |
| Start date | 6 April 2023 |
| Primary completion | 30 October 2024 |
| Estimated completion | 30 December 2024 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Saliva obtaining
Conditions studied
- Aligner Treatment — all drugs for Aligner Treatment →
Sponsor
Izmir Katip Celebi University
Who can join
Adults 18 to 30, any sex, with Aligner Treatment. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study was to determine the effect of orthodontic treatment with aligner on changes in osteoprotegerin (OPG) and receptor activator of NF-κB ligand (RANKL) levels in saliva samples and to investigate the possible relationship between periodontal clinical parameters. Materials and Methods: A total of 25 (n=25) saliva samples were taken from systemically healthy non-smoking individuals who were planned to receive orthodontic treatment with aligner before treatment. Whole mouth clinical periodontal measurements including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI) and plaque index (PI) were also recorded and repeated at 1 and 3 months. Enzyme-linked immunosorbent assay (ELISA) was used to determine OPG and RANKL levels in biological samples.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06646705
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other trials of Saliva obtaining
Trials testing the same drug.
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- NCT06186908 — Evaluation of Salivary Gal-7, Gal-10 and MMP-9 Levels of Individuals With Different Periodontal Diseases · NA · recruiting
- NCT06402877 — Evaluation of Salivary Adseverin, 1-Alpha Defensin and sRANKL Levels of Individuals With Different Periodontal Diseases · NA · completed
Other Izmir Katip Celebi University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06646705 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Izmir Katip Celebi University
- Last refreshed: 17 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06646705.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing